| 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013 | 158 | 2013 |
| Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ... Journal of medicinal chemistry 55 (14), 6639-6643, 2012 | 141 | 2012 |
| Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition J Brem, SS Van Berkel, WS Aik, AM Rydzik, MB Avison, I Pettinati, ... Nature chemistry 6 (12), 1084-1090, 2014 | 130 | 2014 |
| Assay platform for clinically relevant metallo-β-lactamases SS van Berkel, J Brem, AM Rydzik, R Salimraj, R Cain, A Verma, ... Journal of medicinal chemistry 56 (17), 6945-6953, 2013 | 116 | 2013 |
| Interaction of avibactam with class B metallo-β-lactamases MI Abboud, C Damblon, J Brem, N Smargiasso, P Mercuri, B Gilbert, ... Antimicrobial agents and chemotherapy 60 (10), 5655-5662, 2016 | 105 | 2016 |
| Synthetic mRNA cap analogs with a modified triphosphate bridge–synthesis, applications and prospects J Jemielity, J Kowalska, AM Rydzik, E Darzynkiewicz New Journal of Chemistry 34 (5), 829-844, 2010 | 83 | 2010 |
| Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ... Nature communications 5 (1), 3423, 2014 | 77 | 2014 |
| Monitoring Conformational Changes in the NDM‐1 Metallo‐β‐lactamase by 19F NMR Spectroscopy AM Rydzik, J Brem, SS van Berkel, I Pfeffer, A Makena, TDW Claridge, ... Angewandte Chemie 126 (12), 3193-3197, 2014 | 66 | 2014 |
| Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain MC Chan, O Atasoylu, E Hodson, A Tumber, IKH Leung, R Chowdhury, ... PLoS One 10 (7), e0132004, 2015 | 58 | 2015 |
| Comparison of Verona integron-borne metallo-β-lactamase (VIM) variants reveals differences in stability and inhibition profiles A Makena, AÖ Düzgün, J Brem, MA McDonough, AM Rydzik, MI Abboud, ... Antimicrobial agents and chemotherapy 60 (3), 1377-1384, 2016 | 57 | 2016 |
| Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis AM Rydzik, M Kulis, M Lukaszewicz, J Kowalska, J Zuberek, ... Bioorganic & medicinal chemistry 20 (5), 1699-1710, 2012 | 56 | 2012 |
| Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′, 5′ bridge containing methylenebis (phosphonate) modification AM Rydzik, M Lukaszewicz, J Zuberek, J Kowalska, ZM Darzynkiewicz, ... Organic & Biomolecular Chemistry 7 (22), 4763-4776, 2009 | 56 | 2009 |
| Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA) C Contreras-Martel, A Amoroso, ECY Woon, A Zervosen, S Inglis, ... ACS chemical biology 6 (9), 943-951, 2011 | 43 | 2011 |
| Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1 J Brem, WB Struwe, AM Rydzik, H Tarhonskaya, I Pfeffer, E Flashman, ... Chemical science 6 (2), 956-963, 2015 | 41 | 2015 |
| Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies MR Baranowski, A Nowicka, AM Rydzik, M Warminski, R Kasprzyk, ... The Journal of organic chemistry 80 (8), 3982-3997, 2015 | 36 | 2015 |
| A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases SR Inglis, M Strieker, AM Rydzik, A Dessen, CJ Schofield Analytical biochemistry 420 (1), 41-47, 2012 | 31 | 2012 |
| Development and Application of a Fluoride‐Detection‐Based Fluorescence Assay for γ‐Butyrobetaine Hydroxylase AM Rydzik, IKH Leung, GT Kochan, A Thalhammer, U Oppermann, ... ChemBioChem 13 (11), 1559-1563, 2012 | 30 | 2012 |
| mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to … AM Rydzik, M Warminski, PJ Sikorski, MR Baranowski, S Walczak, ... Nucleic Acids Research 45 (15), 8661-8675, 2017 | 25 | 2017 |
| 19F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase MI Abboud, P Hinchliffe, J Brem, R Macsics, I Pfeffer, A Makena, ... Angewandte Chemie 129 (14), 3920-3924, 2017 | 25 | 2017 |
| Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors J Brem, T Panduwawala, JU Hansen, J Hewitt, E Liepins, P Donets, ... Nature Chemistry 14 (1), 15-24, 2022 | 24 | 2022 |
Tim ClaridgeDepartment of Chemistry, University of OxfordAdresse e-mail validée de chem.ox.ac.uk
