Anna Rydzik
Anna Rydzik
AstraZeneca, Medicinal Chemistry, Mölndal, Sweden
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5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical Science 4 (8), 3110-3117, 2013
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition
J Brem, SS Van Berkel, WS Aik, AM Rydzik, MB Avison, I Pettinati, ...
Nature chemistry 6 (12), 1084-1090, 2014
Assay platform for clinically relevant metallo-β-lactamases
SS van Berkel, J Brem, AM Rydzik, R Salimraj, R Cain, A Verma, ...
Journal of medicinal chemistry 56 (17), 6945-6953, 2013
Interaction of avibactam with class B metallo-β-lactamases
MI Abboud, C Damblon, J Brem, N Smargiasso, P Mercuri, B Gilbert, ...
Antimicrobial agents and chemotherapy 60 (10), 5655-5662, 2016
Synthetic mRNA cap analogs with a modified triphosphate bridge–synthesis, applications and prospects
J Jemielity, J Kowalska, AM Rydzik, E Darzynkiewicz
New Journal of Chemistry 34 (5), 829-844, 2010
Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases
H Tarhonskaya, AM Rydzik, IKH Leung, ND Loik, MC Chan, A Kawamura, ...
Nature communications 5 (1), 1-10, 2014
Monitoring Conformational Changes in the NDM‐1 Metallo‐β‐lactamase by 19F NMR Spectroscopy
AM Rydzik, J Brem, SS van Berkel, I Pfeffer, A Makena, TDW Claridge, ...
Angewandte Chemie 126 (12), 3193-3197, 2014
Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′, 5′ bridge containing methylenebis (phosphonate) modification
AM Rydzik, M Lukaszewicz, J Zuberek, J Kowalska, ZM Darzynkiewicz, ...
Organic & Biomolecular Chemistry 7 (22), 4763-4776, 2009
Comparison of Verona integron-borne metallo-β-lactamase (VIM) variants reveals differences in stability and inhibition profiles
A Makena, AÖ Düzgün, J Brem, MA McDonough, AM Rydzik, MI Abboud, ...
Antimicrobial agents and chemotherapy 60 (3), 1377-1384, 2015
Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain
MC Chan, O Atasoylu, E Hodson, A Tumber, IKH Leung, R Chowdhury, ...
PLoS One 10 (7), e0132004, 2015
Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis
AM Rydzik, M Kulis, M Lukaszewicz, J Kowalska, J Zuberek, ...
Bioorganic & medicinal chemistry 20 (5), 1699-1710, 2012
Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1
J Brem, WB Struwe, AM Rydzik, H Tarhonskaya, I Pfeffer, E Flashman, ...
Chemical science 6 (2), 956-963, 2015
Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance in Staphylococcus aureus (MRSA)
C Contreras-Martel, A Amoroso, ECY Woon, A Zervosen, S Inglis, ...
ACS chemical biology 6 (9), 943-951, 2011
Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies
MR Baranowski, A Nowicka, AM Rydzik, M Warminski, R Kasprzyk, ...
The Journal of organic chemistry 80 (8), 3982-3997, 2015
A boronic-acid-based probe for fluorescence polarization assays with penicillin binding proteins and β-lactamases
SR Inglis, M Strieker, AM Rydzik, A Dessen, CJ Schofield
Analytical biochemistry 420 (1), 41-47, 2012
Development and Application of a Fluoride‐Detection‐Based Fluorescence Assay for γ‐Butyrobetaine Hydroxylase
AM Rydzik, IKH Leung, GT Kochan, A Thalhammer, U Oppermann, ...
ChemBioChem 13 (11), 1559-1563, 2012
19F‐NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo‐β‐Lactamase
MI Abboud, P Hinchliffe, J Brem, R Macsics, I Pfeffer, A Makena, ...
Angewandte Chemie International Edition 56 (14), 3862-3866, 2017
Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases
D Zhang, MS Markoulides, D Stepanovs, AM Rydzik, A El-Hussein, C Bon, ...
Bioorganic & medicinal chemistry 26 (11), 2928-2936, 2018
Modulating carnitine levels by targeting its biosynthesis–selective inhibition of γ-butyrobetaine hydroxylase
AM Rydzik, R Chowdhury, GT Kochan, ST Williams, MA McDonough, ...
Chemical science 5 (5), 1765-1771, 2014
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