| Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein CT Lemke, S Titolo, U von Schwedler, N Goudreau, JF Mercier, ... Journal of virology 86 (12), 6643-6655, 2012 | 152 | 2012 |
| Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes L Lamorte, S Titolo, CT Lemke, N Goudreau, JF Mercier, E Wardrop, ... Antimicrobial agents and chemotherapy 57 (10), 4622-4631, 2013 | 127 | 2013 |
| Discovery of a 1, 5-dihydrobenzo [b][1, 4] diazepine-2, 4-dione series of inhibitors of HIV-1 capsid assembly LD Fader, R Bethell, P Bonneau, M Bös, Y Bousquet, MG Cordingley, ... Bioorganic & medicinal chemistry letters 21 (1), 398-404, 2011 | 112 | 2011 |
| Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers T Ito, MJ Young, R Li, S Jain, A Wernitznig, JM Krill-Burger, CT Lemke, ... Nature genetics 53 (12), 1664-1672, 2021 | 79 | 2021 |
| Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335 CT Lemke, N Goudreau, S Zhao, O Hucke, D Thibeault, M Llinas-Brunet, ... Journal of Biological Chemistry 286 (13), 11434-11443, 2011 | 66 | 2011 |
| Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography N Goudreau, CT Lemke, AM Faucher, C Grand-Maître, S Goulet, ... ACS chemical biology 8 (5), 1074-1082, 2013 | 57 | 2013 |
| Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease SR LaPlante, H Nar, CT Lemke, A Jakalian, N Aubry, SH Kawai Journal of Medicinal Chemistry 57 (5), 1777-1789, 2014 | 55 | 2014 |
| Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila DH Fong, CT Lemke, J Hwang, B Xiong, AM Berghuis Journal of biological chemistry 285 (13), 9545-9555, 2010 | 49 | 2010 |
| The 1.6 Å crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis CT Lemke, PL Howell Structure 9 (12), 1153-1164, 2001 | 46 | 2001 |
| S-SAD, Se-SAD and S/Se-SIRAS using Cu Kα radiation: why wait for synchrotron time? CT Lemke, GD Smith, PL Howell Acta Crystallographica Section D: Biological Crystallography 58 (12), 2096-2101, 2002 | 44 | 2002 |
| Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase CW Garvie, X Wu, M Papanastasiou, S Lee, J Fuller, GR Schnitzler, ... Nature Communications 12 (1), 4375, 2021 | 43 | 2021 |
| Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole … M Tremblay, P Bonneau, Y Bousquet, P DeRoy, J Duan, M Duplessis, ... Bioorganic & medicinal chemistry letters 22 (24), 7512-7517, 2012 | 41 | 2012 |
| Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity SR LaPlante, P Forgione, C Boucher, R Coulombe, J Gillard, O Hucke, ... Journal of Medicinal Chemistry 57 (5), 1944-1951, 2014 | 40 | 2014 |
| A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization CT Lemke, N Goudreau, AM Faucher, SW Mason, P Bonneau Acta Crystallographica Section D: Biological Crystallography 69 (6), 1115-1123, 2013 | 38 | 2013 |
| Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex JJ Kwon, B Hajian, Y Bian, LC Young, AJ Amor, JR Fuller, CV Fraley, ... Nature 609 (7926), 408-415, 2022 | 37 | 2022 |
| Potent triazolyl-proline-based inhibitors of HCV NS3 protease J Naud, C Lemke, N Goudreau, E Beaulieu, PD White, M Llinàs-Brunet, ... Bioorganic & medicinal chemistry letters 18 (11), 3400-3404, 2008 | 33 | 2008 |
| Substrate Induced Conformational Changes in Argininosuccinate Synthetase∗ CT Lemke, PL Howell Journal of Biological Chemistry 277 (15), 13074-13081, 2002 | 29 | 2002 |
| Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance JA O'Meara, CT Lemke, C Godbout, G Kukolj, L Lagacé, B Moreau, ... Journal of Biological Chemistry 288 (8), 5673-5681, 2013 | 26 | 2013 |
| Optimization of a 1, 5-dihydrobenzo [b][1, 4] diazepine-2, 4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety LD Fader, S Landry, S Goulet, S Morin, SH Kawai, Y Bousquet, I Dion, ... Bioorganic & medicinal chemistry letters 23 (11), 3401-3405, 2013 | 23 | 2013 |
| Optimization of a 1, 5-dihydrobenzo [b][1, 4] diazepine-2, 4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification LD Fader, S Landry, S Morin, SH Kawai, Y Bousquet, O Hucke, ... Bioorganic & medicinal chemistry letters 23 (11), 3396-3400, 2013 | 20 | 2013 |
