Florian Douam
Florian Douam
Assistant Professor - Boston University School of Medicine and NEIDL
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SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
DW Sanders, CC Jumper, PJ Ackerman, D Bracha, A Donlic, H Kim, ...
Elife 10, e65962, 2021
Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease
Q Ding, JM Gaska, F Douam, L Wei, D Kim, M Balev, B Heller, A Ploss
Proceedings of the National Academy of Sciences 115 (27), E6310-E6318, 2018
Yellow fever virus: knowledge gaps impeding the fight against an old foe
F Douam, A Ploss
Trends in microbiology 26 (11), 913-928, 2018
The mechanism of HCV entry into host cells
F Douam, D Lavillette, FL Cosset
Progress in molecular biology and translational science 129, 63-107, 2015
Critical interaction between E1 and E2 glycoproteins determines binding and fusion properties of hepatitis C virus during cell entry
F Douam, VL Dao Thi, G Maurin, J Fresquet, D Mompelat, MB Zeisel, ...
Hepatology 59 (3), 776-788, 2014
SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway
DY Chen, N Khan, BJ Close, RK Goel, B Blum, AH Tavares, D Kenney, ...
Journal of virology 95 (19), 10.1128/jvi. 00862-21, 2021
Plant science and agricultural productivity: why are we hitting the yield ceiling?
SB de Ribou, F Douam, O Hamant, MW Frohlich, I Negrutiu
Plant Science 210, 159-176, 2013
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation
DY Chen, CV Chin, D Kenney, AH Tavares, N Khan, HL Conway, GQ Liu, ...
Nature 615 (7950), 143-150, 2023
Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo
F Douam, YE Soto Albrecht, G Hrebikova, E Sadimin, C Davidson, ...
MBio 8 (4), 10.1128/mbio. 00819-17, 2017
Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection
S Bocchetta, P Maillard, M Yamamoto, C Gondeau, F Douam, S Lebreton, ...
PloS one 9 (3), e92140, 2014
Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2
I Boo, K teWierik, F Douam, D Lavillette, P Poumbourios, HE Drummer
Biochemical Journal 443 (1), 85-94, 2012
The antimalarial ferroquine is an inhibitor of hepatitis C virus
T Vausselin, N Calland, S Belouzard, V Descamps, F Douam, F Helle, ...
Hepatology 58 (1), 86-97, 2013
Fatal neurodissemination and SARS-CoV-2 tropism in K18-hACE2 mice is only partially dependent on hACE2 expression
M Carossino, D Kenney, AK O’Connell, P Montanaro, AE Tseng, ...
Viruses 14 (3), 535, 2022
Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
F Douam, CGK Ziegler, G Hrebikova, B Fant, R Leach, L Parsons, ...
Nature communications 9 (1), 5031, 2018
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication
M Loffredo, H Lucero, DY Chen, A O’Connell, S Bergqvist, A Munawar, ...
Scientific reports 11 (1), 5433, 2021
A lentiviral vector allowing physiologically regulated membrane-anchored and secreted antibody expression depending on B-cell maturation status
F Fusil, S Calattini, F Amirache, J Mancip, C Costa, JB Robbins, F Douam, ...
Molecular Therapy 23 (11), 1734-1747, 2015
Genetic dissection of the host tropism of human-tropic pathogens
F Douam, JM Gaska, BY Winer, Q Ding, M Von Schaewen, A Ploss
Annual review of genetics 49, 21-45, 2015
Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression
M Carossino, P Montanaro, A O’Connell, D Kenney, H Gertje, KA Grosz, ...
Biorxiv, 2021.01. 13.425144, 2021
Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry
W Ren, Y Zhu, Y Wang, H Shi, Y Yu, G Hu, F Feng, X Zhao, J Lan, J Wu, ...
PLoS pathogens 17 (3), e1009392, 2021
The use of humanized mice for studies of viral pathogenesis and immunity
F Douam, A Ploss
Current opinion in virology 29, 62-71, 2018
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