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Hélène Léger
Hélène Léger
Coimbra Institute for Clinical and Biomedical Research (Portugal)
Adresse e-mail validée de uc.pt
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TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3negCD127+ immune cells in spleen and mucosa
L Van Maele, C Carnoy, D Cayet, P Songhet, L Dumoutier, I Ferrero, ...
The Journal of Immunology 185 (2), 1177-1185, 2010
1552010
Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17-and IFN-γ-mediated immunity
JM Marqués, A Rial, N Muñoz, FX Pellay, L Van Maele, H Léger, T Camou, ...
Immunobiology 217 (4), 420-429, 2012
772012
Key Role for Respiratory CD103+ Dendritic Cells, IFN-γ, and IL-17 in Protection Against Streptococcus pneumoniae Infection in Response to α-Galactosylceramide
S Ivanov, J Fontaine, C Paget, E Macho Fernandez, L Van Maele, ...
The Journal of infectious diseases 206 (5), 723-734, 2012
652012
SUMO-1 regulates the conformational dynamics of thymine-DNA glycosylase regulatory domain and competes with its DNA binding activity
C Smet-Nocca, JM Wieruszeski, H Léger, S Eilebrecht, A Benecke
BMC biochemistry 12, 1-15, 2011
582011
A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes
H Léger, C Smet-Nocca, A Attmane-Elakeb, S Morley-Fletcher, ...
Genomics, Proteomics and Bioinformatics 12 (1), 8-18, 2014
312014
Toll-like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection
G Moreno, A Errea, L Van Maele, R Roberts, H Léger, JC Sirard, ...
Microbes and infection 15 (10-11), 708-718, 2013
312013
HMGA1-dependent and independent 7SK RNA gene regulatory activity
S Eilebrecht, C Bécavin, H Léger, BJ Benecke, A Benecke
RNA biology 8 (1), 143-157, 2011
232011
Ndr kinases regulate retinal interneuron proliferation and homeostasis
H Léger, E Santana, NA Leu, ET Smith, WA Beltran, GD Aguirre, FC Luca
Scientific Reports 8 (1), 12544, 2018
162018
Preparation of mouse retinal cryo-sections for immunohistochemistry
H Léger, E Santana, WA Beltran, FC Luca
JoVE (Journal of Visualized Experiments), e59683, 2019
122019
Alternative splicing of TAF6: downstream transcriptome impacts and upstream RNA splice control elements
C Kamtchueng, ME Stébenne, A Delannoy, E Wilhelm, H Léger, ...
PLoS One 9 (7), e102399, 2014
72014
The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system
PF Santos, B Fazendeiro, FC Luca, AF Ambrósio, H Léger
European Journal of Cell Biology 102 (2), 151333, 2023
42023
The Importance of Kinases in Retinal Degenerative Diseases
PF Santos, AF Ambrósio, H Léger
Kinases and Phosphatases 2 (1), 93-109, 2024
2024
Sitagliptin, an anti‐diabetic drug, inhibits the pro‐inflammatory microglia reactivity via dipeptidyl peptidase‐4 (DPP4)
H Léger, C Leote, L Bufano, R Boia, AR Santiago, R Fernandes, ...
Acta Ophthalmologica 102, 2024
2024
Sitagliptin, a drug for type 2 diabetes, inhibits microglia reactivity triggered by exposure to lipopolysaccharide
AF Ambrosio, S Correia, L Bufano, C Leote, R Boia, AR Santiago, ...
GLIA 71, E850-E850, 2023
2023
Sitagliptin, a drug for type 2 diabetes, significantly inhibits the pro-inflammatory microglia reactivity
AF Ambrósio, S Correia, L Bufano, C Leote, R Boia, AR Santiago, ...
Investigative Ophthalmology & Visual Science 64 (8), 1006-1006, 2023
2023
The Dipeptidyl Peptidase 4 (DPP-4) Inhibitor, Sitagliptin, Exerts Direct Anti-inflammatory Effects on Microglial Cells
AF Ambrosio, S Correia, L Bufano, C Leote, R Boia, AR Santiago, ...
EUROPEAN JOURNAL OF OPHTHALMOLOGY 33 (1), 14-15, 2023
2023
Grandma's stress programs transgenerational transmission of hippocampal glutamatergic synaptopathy associated with stress-related responses
S Morley-Fletcher, J Marrocco, H Léger, J Mairesse, ML Reynaert, ...
Psychoneuroendocrinology 107, 58, 2019
2019
NDR kinases regulate retinal development, homeostasis and gene expression
HM Léger, DP Beiting, WA Beltran, GD Aguirre, F Luca
Investigative Ophthalmology & Visual Science 58 (8), 353-353, 2017
2017
Étude fonctionnelle du complexe CBP/TDG/RARα dans la régulation épigénétique de la transcription et la réparation de l’ADN: couplage entre la réparation de l’ADN, la …
H Leger
Lille 1, 2012
2012
TLR5 Signaling Stimulates the Innate
AB Sebbane, JC Renauld, FE Janot, J Bertout, H Leger, FP Songhet, ...
2010
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