| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 436 | 2018 |
| Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase SH Min, AW Lau, TH Lee, H Inuzuka, S Wei, P Huang, S Shaik, DY Lee, ... Molecular cell 46 (6), 771-783, 2012 | 161 | 2012 |
| Recent advances in the development of Mcl-1 inhibitors for cancer therapy AW Hird, AE Tron Pharmacology & therapeutics 198, 59-67, 2019 | 136 | 2019 |
| Redox regulation of plant homeodomain transcription factors AE Tron, CW Bertoncini, RL Chan, DH Gonzalez Journal of Biological Chemistry 277 (38), 34800-34807, 2002 | 117 | 2002 |
| Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction D Gao, L Wan, H Inuzuka, AH Berg, A Tseng, B Zhai, S Shaik, E Bennett, ... Molecular cell 39 (5), 797-808, 2010 | 112 | 2010 |
| Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface DM Duda, JL Olszewski, AE Tron, M Hammel, LJ Lambert, MB Waddell, ... Molecular cell 47 (3), 371-382, 2012 | 87 | 2012 |
| PARC and CUL7 form atypical cullin RING ligase complexes JR Skaar, L Florens, T Tsutsumi, T Arai, A Tron, SK Swanson, ... Cancer research 67 (5), 2006-2014, 2007 | 85 | 2007 |
| The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 AE Tron, T Arai, DM Duda, H Kuwabara, JL Olszewski, Y Fujiwara, ... Molecular cell 46 (1), 67-78, 2012 | 72 | 2012 |
| SCFβ-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration J Zhong, S Shaik, L Wan, AE Tron, Z Wang, L Sun, H Inuzuka, W Wei Oncotarget 4 (12), 2339, 2013 | 55 | 2013 |
| Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies J Montero, C Gstalder, DJ Kim, D Sadowicz, W Miles, M Manos, ... Nature communications 10 (1), 5157, 2019 | 52 | 2019 |
| Positively charged residues at the N-terminal arm of the homeodomain are required for efficient DNA binding by homeodomain-leucine zipper proteins CM Palena, AE Tron, CW Bertoncini, DH Gonzalez, RL Chan Journal of molecular biology 308 (1), 39-47, 2001 | 50 | 2001 |
| Combinatorial interactions of two amino acids with a single base pair define target site specificity in plant dimeric homeodomain proteins AE Tron, CW Bertoncini, CM Palena, RL Chan, DH Gonzalez Nucleic Acids Research 29 (23), 4866-4872, 2001 | 47 | 2001 |
| Concurrent inhibition of Pim and FLT3 kinases enhances apoptosis of FLT3-ITD acute myeloid leukemia cells through increased Mcl-1 proteasomal degradation S Kapoor, K Natarajan, PR Baldwin, KA Doshi, RG Lapidus, TJ Mathias, ... Clinical Cancer Research 24 (1), 234-247, 2018 | 35 | 2018 |
| Engineering the loop region of a homeodomain-leucine zipper protein promotes efficient binding to a monomeric DNA binding site AE Tron, E Welchen, DH Gonzalez Biochemistry 43 (50), 15845-15851, 2004 | 30 | 2004 |
| Structure of homeodomain-leucine zipper/DNA complexes studied using hydroxyl radical cleavage of DNA and methylation interference AE Tron, RN Comelli, DH Gonzalez Biochemistry 44 (51), 16796-16803, 2005 | 20 | 2005 |
| Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress KA Doshi, R Trotta, K Natarajan, FV Rassool, AE Tron, D Huszar, ... Oncotarget 7 (30), 48280, 2016 | 18 | 2016 |
| Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma P Chuntova, A Yamamichi, T Chen, R Narayanaswamy, S Ronseaux, ... Journal for immunotherapy of cancer 10 (5), 2022 | 15 | 2022 |
| Discovery of M-1121 as an orally active covalent inhibitor of menin-MLL interaction capable of achieving complete and long-lasting tumor regression M Zhang, A Aguilar, S Xu, L Huang, K Chinnaswamy, T Sleger, B Wang, ... Journal of medicinal chemistry 64 (14), 10333-10349, 2021 | 13 | 2021 |
| Next-generation sequencing identifies a novel ELAVL1–TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208 AE Tron, EK Keeton, M Ye, M Casas-Selves, H Chen, KS Dillman, ... Leukemia & lymphoma 57 (12), 2927-2929, 2016 | 13 | 2016 |
| Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells E Gruber, J So, AC Lewis, R Franich, R Cole, LG Martelotto, AJ Rogers, ... Cell Reports 40 (7), 2022 | 7 | 2022 |
