Jean-Pierre Jaffrézou
Jean-Pierre Jaffrézou
CNRS Researcher (CR1), Cerco (CNRS-UT3), TMBI (Univ. Toulouse)
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Cited by
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Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
A Quillet-Mary, JP Jaffrézou, V Mansat, C Bordier, J Naval, G Laurent
Journal of Biological Chemistry 272 (34), 21388-21395, 1997
Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
JP Jaffrezou, T Levade, A Bettaieb, N Andrieu, C Bezombes, N Maestre, ...
The EMBO journal 15 (10), 2417-2424, 1996
Signalling sphingomyelinases: which, where, how and why?
T Levade, JP Jaffrézou
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 1999
L‐carnitine prevents doxorubicin‐induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation
N Andrieu‐Abadie, JP Jaffrézou, S Hatem, G Laurent, T Levade, ...
The FASEB Journal 13 (12), 1501-1510, 1999
Signaling pathways activated by daunorubicin
G Laurent, JP Jaffrézou
Blood 98 (4), 913-924, 2001
Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin
V Mansat-De Mas, C Bezombes, A Quillet-Mary, A Bettaïeb, G Laurent, ...
Molecular Pharmacology 56 (5), 867-874, 1999
Restoration of TNF‐α‐induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P‐glycoprotein blocker PSC833
C Bezombes, N Maestre, G Laurent, T Levade, A Bettaïeb, JP Jaffrézou
The FASEB Journal 12 (1), 101-109, 1998
UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal
A Charruyer, S Grazide, C Bezombes, S Müller, G Laurent, JP Jaffrézou
Journal of Biological Chemistry 280 (19), 19196-19204, 2005
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains
C Bezombes, S Grazide, C Garret, C Fabre, A Quillet-Mary, S Müller, ...
Blood 104 (4), 1166-1173, 2004
Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines.
JD Bailly, C Muller, JP Jaffrezou, C Demur, G Gassar, C Bordier, ...
Leukemia 9 (5), 799-807, 1995
Sphingolipids as modulators of cancer cell death: potential therapeutic targets
B Ségui, N Andrieu-Abadie, JP Jaffrézou, H Benoist, T Levade
Biochimica et Biophysica Acta (BBA)-Biomembranes 1758 (12), 2104-2120, 2006
p38 MAPK mediates the regulation of α1 (I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells
M Varela-Rey, C Montiel-Duarte, JA Oses-Prieto, MJ Lopez-Zabalza, ...
FEBS letters 528 (1-3), 133-138, 2002
Novel mechanism of resistance to paclitaxel (Taxol®) in human K562 leukemia cells by combined selection with PSC 833
JP Jaffrezou, C Dumontet, WB Derry, G Duran, G Chen, E Tsuchiya, ...
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 7 …, 1995
Prevalence of multidrug resistance related to activation of the mdr1 gene in human sarcoma mutants derived by single-step doxorubicin selection
G Chen, JP Jaffrézou, WH Fleming, GE Durán, BI Sikic
Cancer research 54 (18), 4980-4987, 1994
Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein
N Augé, I Escargueil-Blanc, I Lajoie-Mazenc, I Suc, N Andrieu-Abadie, ...
Journal of Biological Chemistry 273 (21), 12893-12900, 1998
The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
V Mansat, G Laurent, T Levade, A Bettaïeb, JP Jaffrézou
Cancer research 57 (23), 5300-5304, 1997
Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.
M Higuchi, S Singh, JP Jaffrezou, BB Aggarwal
The Journal of Immunology 157 (1), 297-304, 1996
Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes
E Delpy, SN Hatem, N Andrieu, C de Vaumas, M Henaff, C Rücker-Martin, ...
Cardiovascular research 43 (2), 398-407, 1999
Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation
AP Bruno, G Laurent, D Averbeck, C Demur, J Bonnet, A Bettaïeb, ...
Cell Death & Differentiation 5 (2), 172-182, 1998
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins
G Chen, GE Durán, KA Steger, NJ Lacayo, JP Jaffrézou, C Dumontet, ...
Journal of Biological Chemistry 272 (9), 5974-5982, 1997
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