| Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis A Quillet-Mary, JP Jaffrézou, V Mansat, C Bordier, J Naval, G Laurent Journal of Biological Chemistry 272 (34), 21388-21395, 1997 | 584 | 1997 |
| Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. JP Jaffrezou, T Levade, A Bettaieb, N Andrieu, C Bezombes, N Maestre, ... The EMBO journal 15 (10), 2417-2424, 1996 | 434 | 1996 |
| Signalling sphingomyelinases: which, where, how and why? T Levade, JP Jaffrézou Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 1999 | 408 | 1999 |
| L‐carnitine prevents doxorubicin‐induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation N Andrieu‐Abadie, JP Jaffrézou, S Hatem, G Laurent, T Levade, ... The FASEB Journal 13 (12), 1501-1510, 1999 | 239 | 1999 |
| Signaling pathways activated by daunorubicin G Laurent, JP Jaffrézou Blood, The Journal of the American Society of Hematology 98 (4), 913-924, 2001 | 226 | 2001 |
| UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal A Charruyer, S Grazide, C Bezombes, S Müller, G Laurent, JP Jaffrézou Journal of Biological Chemistry 280 (19), 19196-19204, 2005 | 168 | 2005 |
| Implication of radical oxygen species in ceramide generation, c-Jun N-terminal kinase activation and apoptosis induced by daunorubicin V Mansat-De Mas, C Bezombes, A Quillet-Mary, A Bettaïeb, G Laurent, ... Molecular Pharmacology 56 (5), 867-874, 1999 | 166 | 1999 |
| Restoration of TNF‐α‐induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P‐glycoprotein blocker PSC833 C Bezombes, N Maestre, G Laurent, T Levade, A Bettaïeb, JP Jaffrézou The FASEB journal 12 (1), 101-109, 1998 | 164 | 1998 |
| Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains C Bezombes, S Grazide, C Garret, C Fabre, A Quillet-Mary, S Müller, ... Blood 104 (4), 1166-1173, 2004 | 161 | 2004 |
| Sphingolipids as modulators of cancer cell death: potential therapeutic targets B Ségui, N Andrieu-Abadie, JP Jaffrézou, H Benoist, T Levade Biochimica et Biophysica Acta (BBA)-Biomembranes 1758 (12), 2104-2120, 2006 | 155 | 2006 |
| Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. JD Bailly, C Muller, JP Jaffrezou, C Demur, G Gassar, C Bordier, ... Leukemia 9 (5), 799-807, 1995 | 146 | 1995 |
| p38 MAPK mediates the regulation of α1 (I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells M Varela-Rey, C Montiel-Duarte, JA Oses-Prieto, MJ Lopez-Zabalza, ... FEBS letters 528 (1-3), 133-138, 2002 | 122 | 2002 |
| Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833. JP Jaffrezou, C Dumontet, WB Derry, G Duran, KG Chen, E Tsuchiya, ... Oncology research 7 (10-11), 517-527, 1995 | 114 | 1995 |
| Prevalence of Multidrug Resistance Related to Activation of the mdr1 Gene in Human Sarcoma Mutants Derived by Single-Step Doxorubicin Selection G Chen, JP Jaffrézou, WH Fleming, GE Durán, BI Sikic Cancer research 54 (18), 4980-4987, 1994 | 111 | 1994 |
| Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes E Delpy, SN Hatem, N Andrieu, C de Vaumas, M Henaff, C Rücker-Martin, ... Cardiovascular research 43 (2), 398-407, 1999 | 108 | 1999 |
| Potential role for ceramide in mitogen-activated protein kinase activation and proliferation of vascular smooth muscle cells induced by oxidized low density lipoprotein N Augé, I Escargueil-Blanc, I Lajoie-Mazenc, I Suc, N Andrieu-Abadie, ... Journal of Biological Chemistry 273 (21), 12893-12900, 1998 | 105 | 1998 |
| Verapamil decreases P‐glycoprotein expression in multidrug‐resistant human leukemic cell lines C Muller, JD Bailly, F Goubin, J Laredo, JP Jaffrézou, C Bordier, ... International journal of cancer 56 (5), 749-754, 1994 | 105 | 1994 |
| Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins G Chen, GE Durán, KA Steger, NJ Lacayo, JP Jaffrézou, C Dumontet, ... Journal of Biological Chemistry 272 (9), 5974-5982, 1997 | 103 | 1997 |
| Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation. M Higuchi, S Singh, JP Jaffrezou, BB Aggarwal Journal of immunology (Baltimore, Md.: 1950) 157 (1), 297-304, 1996 | 99 | 1996 |
| The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin V Mansat, G Laurent, T Levade, A Bettaïeb, JP Jaffrézou Cancer research 57 (23), 5300-5304, 1997 | 95 | 1997 |
Raphaëlle N. RoyProfessor (PhD, Habil.) at ISAE-SUPAERO, Université de Toulouse, FranceVerified email at isae.fr
