Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors P Kemmeren, K Sameith, LAL Van De Pasch, JJ Benschop, TL Lenstra, ... Cell 157 (3), 740-752, 2014 | 321 | 2014 |
The specificity and topology of chromatin interaction pathways in yeast TL Lenstra, JJ Benschop, TS Kim, JM Schulze, NACH Brabers, ... Molecular cell 42 (4), 536-549, 2011 | 258 | 2011 |
Transcription dynamics in living cells TL Lenstra, J Rodriguez, H Chen, DR Larson Annual review of biophysics 45, 25-47, 2016 | 176 | 2016 |
Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting BT Donovan, A Huynh, DA Ball, HP Patel, MG Poirier, DR Larson, ... The EMBO journal 38 (12), e100809, 2019 | 162 | 2019 |
Functional overlap and regulatory links shape genetic interactions between signaling pathways S van Wageningen, P Kemmeren, P Lijnzaad, T Margaritis, JJ Benschop, ... Cell 143 (6), 991-1004, 2010 | 148 | 2010 |
Single-molecule imaging reveals a switch between spurious and functional ncRNA transcription TL Lenstra, A Coulon, CC Chow, DR Larson Molecular cell 60 (4), 597-610, 2015 | 120 | 2015 |
Cell cycle population effects in perturbation studies E O'Duibhir, P Lijnzaad, JJ Benschop, TL Lenstra, D van Leenen, ... Molecular systems biology 10 (6), 732, 2014 | 114 | 2014 |
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs MC Daugeron, TL Lenstra, M Frizzarin, B El Yacoubi, X Liu, ... Nucleic acids research 39 (14), 6148-6160, 2011 | 95 | 2011 |
Visualizing transcription: key to understanding gene expression dynamics I Brouwer, TL Lenstra Current opinion in chemical biology 51, 122-129, 2019 | 61 | 2019 |
Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis C Hartzell, O Ksionda, E Lemmens, K Coakley, M Yang, M Dail, ... Science signaling 6 (268), ra21-ra21, 2013 | 55 | 2013 |
Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation JE Haber, H Braberg, Q Wu, R Alexander, J Haase, C Ryan, ... Cell reports 3 (6), 2168-2178, 2013 | 49 | 2013 |
RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting P Quintero-Cadena, TL Lenstra, PW Sternberg Molecular cell 79 (2), 207-220. e8, 2020 | 45 | 2020 |
Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism T van Welsem, T Korthout, R Ekkebus, D Morais, TM Molenaar, ... Nucleic acids research 46 (21), 11251-11261, 2018 | 35 | 2018 |
A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover KF Verzijlbergen, T van Welsem, D Sie, TL Lenstra, DJ Turner, ... PLoS genetics 7 (10), e1002284, 2011 | 34 | 2011 |
Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions X Fu, HP Patel, S Coppola, L Xu, Z Cao, TL Lenstra, R Grima Elife 11, e82493, 2022 | 33 | 2022 |
Dot1 binding induces chromatin rearrangements by histone methylation-dependent and-independent mechanisms IJE Stulemeijer, BL Pike, AW Faber, KF Verzijlbergen, T van Welsem, ... Epigenetics & chromatin 4, 1-14, 2011 | 33 | 2011 |
Single‐molecule mRNA detection in live yeast TL Lenstra, DR Larson Current protocols in molecular biology 113 (1), 14.24. 1-14.24. 15, 2016 | 29 | 2016 |
Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast TM Ng, TL Lenstra, N Duggan, S Jiang, S Ceto, FCP Holstege, J Dai, ... Genetics 195 (3), 795-807, 2013 | 26 | 2013 |
A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions K Sameith, S Amini, MJA Groot Koerkamp, D van Leenen, M Brok, ... BMC biology 13, 1-16, 2015 | 24 | 2015 |
The role of Ctk1 kinase in termination of small non-coding RNAs TL Lenstra, A Tudek, S Clauder, Z Xu, ST Pachis, D van Leenen, ... PLoS One 8 (12), e80495, 2013 | 24 | 2013 |