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Jeff Franklin
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Reassessment of exosome composition
DK Jeppesen, AM Fenix, JL Franklin, JN Higginbotham, Q Zhang, ...
Cell 177 (2), 428-445. e18, 2019
20162019
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor
AE Powell, Y Wang, Y Li, EJ Poulin, AL Means, MK Washington, ...
Cell 149 (1), 146-158, 2012
7482012
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS
MD Beckler, JN Higginbotham, JL Franklin, AJ Ham, PJ Halvey, ...
Molecular & cellular proteomics 12 (2), 343-355, 2013
5912013
KRAS-MEK signaling controls Ago2 sorting into exosomes
AJ McKenzie, D Hoshino, NH Hong, DJ Cha, JL Franklin, RJ Coffey, ...
Cell reports 15 (5), 978-987, 2016
4022016
Amphiregulin exosomes increase cancer cell invasion
JN Higginbotham, MD Beckler, JD Gephart, JL Franklin, G Bogatcheva, ...
Current Biology 21 (9), 779-786, 2011
3982011
KRAS-dependent sorting of miRNA to exosomes
DJ Cha, JL Franklin, Y Dou, Q Liu, JN Higginbotham, M Demory Beckler, ...
Elife 4, e07197, 2015
3692015
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
S Kaiser, YK Park, JL Franklin, RB Halberg, M Yu, WJ Jessen, ...
Genome biology 8, 1-26, 2007
3572007
lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling
Y Lu, X Zhao, Q Liu, C Li, R Graves-Deal, Z Cao, B Singh, JL Franklin, ...
Nature medicine 23 (11), 1331-1341, 2017
3552017
Transfer of functional cargo in exomeres
Q Zhang, JN Higginbotham, DK Jeppesen, YP Yang, W Li, ET McKinley, ...
Cell reports 27 (3), 940-954. e6, 2019
3102019
Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes
Y Dou, DJ Cha, JL Franklin, JN Higginbotham, DK Jeppesen, AM Weaver, ...
Scientific reports 6 (1), 37982, 2016
3012016
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Q Zhang, DK Jeppesen, JN Higginbotham, R Graves-Deal, VQ Trinh, ...
Nature cell biology 23 (12), 1240-1254, 2021
2032021
Unsupervised trajectory analysis of single-cell RNA-seq and imaging data reveals alternative tuft cell origins in the gut
CA Herring, A Banerjee, ET McKinley, AJ Simmons, J Ping, JT Roland, ...
Cell systems 6 (1), 37-51. e9, 2018
1972018
Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1
JL Franklin, BE Berechid, FB Cutting, A Presente, CB Chambers, DR Foltz, ...
Current Biology 9 (24), 1448-1457, 1999
1921999
The extracellular RNA communication consortium: establishing foundational knowledge and technologies for extracellular RNA research
S Das, AB Abdel-Mageed, C Adamidi, PD Adelson, KM Akat, E Alsop, ...
Cell 177 (2), 231-242, 2019
1722019
Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism
NM Chumbler, MA Farrow, LA Lapierre, JL Franklin, D Haslam, ...
PLoS pathogens 8 (12), e1003072, 2012
1432012
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
B Chen, S Cherie’R, ET McKinley, AJ Simmons, MA Ramirez-Solano, ...
Cell 184 (26), 6262-6280. e26, 2021
1392021
Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells
SA Hinger, DJ Cha, JL Franklin, JN Higginbotham, Y Dou, J Ping, L Shu, ...
Cell reports 25 (3), 715-725. e4, 2018
1342018
Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex
MA Farrow, NM Chumbler, LA Lapierre, JL Franklin, SA Rutherford, ...
Proceedings of the National Academy of Sciences 110 (46), 18674-18679, 2013
1332013
Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity
ET McKinley, Y Sui, Y Al-Kofahi, BA Millis, MJ Tyska, JT Roland, ...
JCI insight 2 (11), 2017
1322017
Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting
JN Higginbotham, Q Zhang, DK Jeppesen, AM Scott, HC Manning, ...
Journal of Extracellular Vesicles 5 (1), 29254, 2016
1202016
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