Luca Pinello
Luca Pinello
Associate Professor, MGH/Harvard Medical School/BROAD Institute
Verified email at - Homepage
Cited by
Cited by
CRISPResso2 provides accurate and rapid genome editing sequence analysis
K Clement, H Rees, MC Canver, JM Gehrke, R Farouni, JY Hsu, MA Cole, ...
Nature biotechnology 37 (3), 224-226, 2019
Eleven grand challenges in single-cell data science
D Lähnemann, J Köster, E Szczurek, DJ McCarthy, SC Hicks, ...
Genome biology 21, 1-35, 2020
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
MC Canver, EC Smith, F Sher, L Pinello, NE Sanjana, O Shalem, ...
Nature 527 (7577), 192-197, 2015
Bioconda: sustainable and comprehensive software distribution for the life sciences
B Grüning, R Dale, A Sjödin, BA Chapman, J Rowe, CH Tomkins-Tinch, ...
Nature methods 15 (7), 475-476, 2018
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
S Beyaz, MD Mana, J Roper, D Kedrin, A Saadatpour, SJ Hong, ...
Nature 531 (7592), 53-58, 2016
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level
DE Bauer, SC Kamran, S Lessard, J Xu, Y Fujiwara, C Lin, Z Shao, ...
Science 342 (6155), 253-257, 2013
Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ...
Nature biotechnology 37 (3), 276-282, 2019
LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity
G Wu, J Cai, Y Han, J Chen, ZP Huang, C Chen, Y Cai, H Huang, Y Yang, ...
Circulation 130 (17), 1452-1465, 2014
BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair
E Hatchi, K Skourti-Stathaki, S Ventz, L Pinello, A Yen, ...
Molecular cell 57 (4), 636-647, 2015
Analyzing CRISPR genome-editing experiments with CRISPResso
L Pinello, MC Canver, MD Hoban, SH Orkin, DB Kohn, DE Bauer, ...
Nature biotechnology 34 (7), 695-697, 2016
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ...
Nature medicine 25 (5), 776-783, 2019
An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
JM Gehrke, O Cervantes, MK Clement, Y Wu, J Zeng, DE Bauer, L Pinello, ...
Nature biotechnology 36 (10), 977-982, 2018
In vivo CRISPR editing with no detectable genome-wide off-target mutations
P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ...
Nature 561 (7723), 416-419, 2018
GiniClust: detecting rare cell types from single-cell gene expression data with Gini index
L Jiang, H Chen, L Pinello, GC Yuan
Genome biology 17, 1-13, 2016
Assessment of computational methods for the analysis of single-cell ATAC-seq data
H Chen, C Lareau, T Andreani, ME Vinyard, SP Garcia, K Clement, ...
Genome biology 20, 1-25, 2019
Therapeutic base editing of human hematopoietic stem cells
J Zeng, Y Wu, C Ren, J Bonanno, AH Shen, D Shea, JM Gehrke, ...
Nature medicine 26 (4), 535-541, 2020
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
H Chen, L Albergante, JY Hsu, CA Lareau, G Lo Bosco, J Guan, S Zhou, ...
Nature communications 10 (1), 1-14, 2019
Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis
J Xu, Z Shao, K Glass, DE Bauer, L Pinello, B Van Handel, S Hou, ...
Developmental cell 23 (4), 796-811, 2012
Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing
Q Tang, S Iyer, R Lobbardi, JC Moore, H Chen, C Lareau, C Hebert, ...
Journal of Experimental Medicine 214 (10), 2875-2887, 2017
Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions
J Xu, Z Shao, D Li, H Xie, W Kim, J Huang, JE Taylor, L Pinello, K Glass, ...
Molecular cell 57 (2), 304-316, 2015
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