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George Kunos
George Kunos
Scientific Director, NIAAA/NIH
Adresse e-mail validée de nih.gov
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The endocannabinoid system as an emerging target of pharmacotherapy
P Pacher, S Bátkai, G Kunos
Pharmacological reviews 58 (3), 389-462, 2006
26142006
Leptin-regulated endocannabinoids are involved in maintaining food intake
V Di Marzo, SK Goparaju, L Wang, J Liu, S Bátkai, Z Járai, F Fezza, ...
Nature 410 (6830), 822-825, 2001
19782001
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2
RG Pertwee, AC Howlett, ME Abood, SPH Alexander, V Di Marzo, ...
Pharmacological reviews 62 (4), 588-631, 2010
19642010
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
D Osei-Hyiaman, M DePetrillo, P Pacher, J Liu, S Radaeva, S Bátkai, ...
The Journal of clinical investigation 115 (5), 1298-1305, 2005
13312005
Nonpsychotropic cannabinoid receptors regulate microglial cell migration
L Walter, A Franklin, A Witting, C Wade, Y Xie, G Kunos, K Mackie, ...
Journal of Neuroscience 23 (4), 1398-1405, 2003
7942003
Endocannabinoid signaling at the periphery: 50 years after THC
M Maccarrone, I Bab, T Bíró, GA Cabral, SK Dey, V Di Marzo, JC Konje, ...
Trends in pharmacological sciences 36 (5), 277-296, 2015
7352015
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
Z Járai, JA Wagner, K Varga, KD Lake, DR Compton, BR Martin, ...
Proceedings of the National Academy of Sciences 96 (24), 14136-14141, 1999
7291999
Presynaptic specificity of endocannabinoid signaling in the hippocampus
RI Wilson, G Kunos, RA Nicoll
Neuron 31 (3), 453-462, 2001
6482001
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
N Agarwal, P Pacher, I Tegeder, F Amaya, CE Constantin, GJ Brenner, ...
Nature neuroscience 10 (7), 870-879, 2007
6372007
A biosynthetic pathway for anandamide
J Liu, L Wang, J Harvey-White, D Osei-Hyiaman, R Razdan, Q Gong, ...
Proceedings of the National Academy of Sciences 103 (36), 13345-13350, 2006
5452006
Evidence for novel cannabinoid receptors
M Begg, P Pacher, S Bátkai, D Osei-Hyiaman, L Offertáler, FM Mo, J Liu, ...
Pharmacology & therapeutics 106 (2), 133-145, 2005
5312005
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity
J Tam, VK Vemuri, J Liu, S Bátkai, B Mukhopadhyay, G Godlewski, ...
The Journal of clinical investigation 120 (8), 2953-2966, 2010
5222010
Platelet‐and macrophage‐derived endogenous cannabinoids are involved in endotoxin‐induced hypotension
K Varga, JA Wagner, DT Bridgen, G Kunos
The FASEB journal 12 (11), 1035-1044, 1998
5201998
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
D Osei-Hyiaman, J Liu, L Zhou, G Godlewski, J Harvey-White, W Jeong, ...
The Journal of clinical investigation 118 (9), 3160-3169, 2008
5042008
Modulating the endocannabinoid system in human health and disease–successes and failures
P Pacher, G Kunos
The FEBS journal 280 (9), 1918-1943, 2013
4662013
Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis
S Bátkai, Z Járai, JA Wagner, SK Goparaju, KÁ Varga, J Liu, L Wang, ...
Nature medicine 7 (7), 827-832, 2001
4612001
Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves
EJN Ishac, L Jiang, KD Lake, K Varga, ME Abood, G Kunos
British journal of pharmacology 118 (8), 2023-2028, 1996
4591996
Functional CB1 cannabinoid receptors in human vascular endothelial cells
J LIU, B GAO, F MIRSHAHI, AJ SANYAL, AD KHANOLKAR, ...
Biochemical Journal 346 (3), 835-840, 2000
4072000
Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly
P Pacher, S Steffens, G Haskó, TH Schindler, G Kunos
Nature Reviews Cardiology 15 (3), 151-166, 2018
3912018
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
T Jourdan, G Godlewski, R Cinar, A Bertola, G Szanda, J Liu, J Tam, ...
Nature medicine 19 (9), 1132-1140, 2013
3872013
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