Michael McDonough
Michael McDonough
Postdoctoral research fellow, Department of Chemistry, University of Oxford
Adresse e-mail validée de chem.ox.ac.uk
TitreCitée parAnnée
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
T Gerken, CA Girard, YCL Tung, CJ Webby, V Saudek, KS Hewitson, ...
Science 318 (5855), 1469-1472, 2007
12842007
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases
R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ...
EMBO reports 12 (5), 463-469, 2011
6562011
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
IJ Clifton, MA McDonough, D Ehrismann, NJ Kershaw, N Granatino, ...
Journal of inorganic biochemistry 100 (4), 644-669, 2006
3852006
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
MA McDonough, V Li, E Flashman, R Chowdhury, C Mohr, BMR Liénard, ...
Proceedings of the National Academy of Sciences 103 (26), 9814-9819, 2006
3182006
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity
SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ...
Nature 448 (7149), 87, 2007
2852007
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
ME Cockman, DE Lancaster, IP Stolze, KS Hewitson, MA McDonough, ...
Proceedings of the National Academy of Sciences 103 (40), 14767-14772, 2006
2642006
Inhibition of 2-oxoglutarate dependent oxygenases
NR Rose, MA McDonough, ONF King, A Kawamura, CJ Schofield
Chemical Society reviews 40 (8), 4364-4397, 2011
2622011
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ...
Biochemical Journal 416 (3), 387-394, 2008
2522008
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
ML Coleman, MA McDonough, KS Hewitson, C Coles, J Mecinović, ...
Journal of Biological Chemistry 282 (33), 24027-24038, 2007
2122007
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
KS Hewitson, BMR Liénard, MA McDonough, IJ Clifton, D Butler, ...
Journal of Biological Chemistry 282 (5), 3293-3301, 2007
2002007
Structural studies on human 2-oxoglutarate dependent oxygenases
MA McDonough, C Loenarz, R Chowdhury, IJ Clifton, CJ Schofield
Current opinion in structural biology 20 (6), 659-672, 2010
1972010
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases
NR Rose, SS Ng, J Mecinovic, BMR Liénard, SH Bello, Z Sun, ...
Journal of medicinal chemistry 51 (22), 7053-7056, 2008
1932008
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases
R Chowdhury, MA McDonough, J Mecinović, C Loenarz, E Flashman, ...
Structure 17 (7), 981-989, 2009
1812009
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches
NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ...
Journal of medicinal chemistry 53 (4), 1810-1818, 2010
1472010
Selective inhibition of factor inhibiting hypoxia-inducible factor
MA McDonough, LA McNeill, M Tilliet, CA Papamicaël, QY Chen, ...
Journal of the American Chemical Society 127 (21), 7680-7681, 2005
1262005
The enzymes of β-lactam biosynthesis
RB Hamed, JR Gomez-Castellanos, L Henry, C Ducho, MA McDonough, ...
Natural product reports 30 (1), 21-107, 2013
1232013
Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases
WS Aik, MA McDonough, A Thalhammer, R Chowdhury, CJ Schofield
Current opinion in structural biology 22 (6), 691-700, 2012
1212012
A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis
W Lee, MA McDonough, LP Kotra, ZH Li, NR Silvaggi, Y Takeda, JA Kelly, ...
Proceedings of the National Academy of Sciences 98 (4), 1427-1431, 2001
1092001
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
992013
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
J Brem, R Cain, S Cahill, MA McDonough, IJ Clifton, ...
Nature communications 7, 12406, 2016
982016
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