Michael McDonough

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Rasheduzzaman ChowdhuryUniversity of Oxford, Stanford University School of Medicine, Cardiovascular Research Institute UCSFAdresse e-mail validée de eternitybioscience.com
Tim ClaridgeDepartment of Chemistry, University of OxfordAdresse e-mail validée de chem.ox.ac.uk
Nathan RoseHead of Regulatory Science, OxitecAdresse e-mail validée de oxitec.com
Wei Shen AikAssistant Professor, Hong Kong Baptist UniversityAdresse e-mail validée de hkbu.edu.hk
Christoph LoenarzProfessor of Pharmaceutical Bioanalytics, University of FreiburgAdresse e-mail validée de pharmazie.uni-freiburg.de
Ivanhoe LeungThe University of MelbourneAdresse e-mail validée de unimelb.edu.au
Anna RydzikAstraZeneca, Medicinal Chemistry, Mölndal, SwedenAdresse e-mail validée de astrazeneca.com
Esther C.Y. WoonUniversity College LondonAdresse e-mail validée de ucl.ac.uk
Neil J OldhamUniversity of NottinghamAdresse e-mail validée de nottingham.ac.uk
Eleanor BaggUniversity of OxfordAdresse e-mail validée de lincoln.oxon.org
Oliver N. F. KingData Analysis Scientist - Machine Vision, Diamond Light Source, UKAdresse e-mail validée de chem.ox.ac.uk
Hwanho ChoiUniversity of OxfordAdresse e-mail validée de chem.ox.ac.uk
Nadia Jean KershawWalter and Eliza Hall InstituteAdresse e-mail validée de wehi.edu.au
Kar Kheng YeohUniversiti Sains MalaysiaAdresse e-mail validée de usm.my
Benedikt KesslerProfessor of Biochemistry and Life Science Mass Spectrometry, University of Oxford, UKAdresse e-mail validée de ndm.ox.ac.uk
Martine I. AbboudUniversity of OxfordAdresse e-mail validée de chem.ox.ac.uk
Grazyna KochanTeam LeaderAdresse e-mail validée de navarra.es
Frank von DelftPrincipal Investigator: Protein Crystallography, SGC, Oxford UniversityAdresse e-mail validée de sgc.ox.ac.uk
Mathew ColemanInstitute of Cancer and Genomic Sciences, University of BirminghamAdresse e-mail validée de bham.ac.uk
colin FishwickProfessor of Medicinal Chemistry, University of LeedsAdresse e-mail validée de leeds.ac.uk

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Michael McDonough

Atomic Resolution Consulting AB

Adresse e-mail validée de atomic-resolution.com - Page d'accueil

Structural Biology


Titre Trier par citations Trier par année Trier par titre	Citée par Citée par	Année
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase T Gerken, CA Girard, YCL Tung, CJ Webby, V Saudek, KS Hewitson, ... Science 318 (5855), 1469-1472, 2007	1691	2007
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases R Chowdhury, KK Yeoh, YM Tian, L Hillringhaus, EA Bagg, NR Rose, ... EMBO reports 12 (5), 463-469, 2011	1023	2011
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins IJ Clifton, MA McDonough, D Ehrismann, NJ Kershaw, N Granatino, ... Journal of inorganic biochemistry 100 (4), 644-669, 2006	491	2006
Inhibition of 2-oxoglutarate dependent oxygenases NR Rose, MA McDonough, ONF King, A Kawamura, CJ Schofield Chemical Society reviews 40 (8), 4364-4397, 2011	391	2011
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) MA McDonough, V Li, E Flashman, R Chowdhury, C Mohr, BMR Liénard, ... Proceedings of the National Academy of Sciences 103 (26), 9814-9819, 2006	384	2006
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity SS Ng, KL Kavanagh, MA McDonough, D Butler, ES Pilka, BMR Lienard, ... Nature 448 (7149), 87-91, 2007	326	2007
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α PJ Pollard, C Loenarz, DR Mole, MA McDonough, JM Gleadle, ... Biochemical Journal 416 (3), 387-394, 2008	316	2008
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) ME Cockman, DE Lancaster, IP Stolze, KS Hewitson, MA McDonough, ... Proceedings of the National Academy of Sciences 103 (40), 14767-14772, 2006	314	2006
Structural studies on human 2-oxoglutarate dependent oxygenases MA McDonough, C Loenarz, R Chowdhury, IJ Clifton, CJ Schofield Current opinion in structural biology 20 (6), 659-672, 2010	296	2010
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates KS Hewitson, BMR Lienard, MA McDonough, IJ Clifton, D Butler, ... Journal of Biological Chemistry 282 (5), 3293-3301, 2007	247	2007
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor ML Coleman, MA McDonough, KS Hewitson, C Coles, J Mecinovicí, ... Journal of Biological Chemistry 282 (33), 24027-24038, 2007	245	2007
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases NR Rose, SS Ng, J Mecinovic, BMR Liénard, SH Bello, Z Sun, ... Journal of medicinal chemistry 51 (22), 7053-7056, 2008	240	2008
Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates J Brem, R Cain, S Cahill, MA McDonough, IJ Clifton, ... Nature communications 7 (1), 12406, 2016	237	2016
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases R Chowdhury, MA McDonough, J Mecinović, C Loenarz, E Flashman, ... Structure 17 (7), 981-989, 2009	221	2009
The enzymes of β-lactam biosynthesis RB Hamed, JR Gomez-Castellanos, L Henry, C Ducho, MA McDonough, ... Natural product reports 30 (1), 21-107, 2013	209	2013
Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases WS Aik, MA McDonough, A Thalhammer, R Chowdhury, CJ Schofield Current opinion in structural biology 22 (6), 691-700, 2012	185	2012
Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers J Brem, SS van Berkel, D Zollman, SY Lee, O Gileadi, PJ McHugh, ... Antimicrobial agents and chemotherapy 60 (1), 142-150, 2016	167	2016
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches NR Rose, ECY Woon, GL Kingham, ONF King, J Mecinovic, IJ Clifton, ... Journal of medicinal chemistry 53 (4), 1810-1818, 2010	166	2010
Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation WS Aik, JS Scotti, H Choi, L Gong, M Demetriades, CJ Schofield, ... Nucleic acids research 42 (7), 4741-4754, 2014	160	2014
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013	158	2013

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