High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows H Azizgolshani, JR Coppeta, EM Vedula, EE Marr, BP Cain, RJ Luu, ... Lab on a Chip 21 (8), 1454-1474, 2021 | 122 | 2021 |
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD AO Awojoodu, PM Keegan, AR Lane, Y Zhang, KR Lynch, MO Platt, ... Blood, The Journal of the American Society of Hematology 124 (12), 1941-1950, 2014 | 92 | 2014 |
A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions K Tan, P Keegan, M Rogers, M Lu, JR Gosset, J Charest, SS Bale Lab on a Chip 19 (9), 1556-1566, 2019 | 77 | 2019 |
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues CL Wilder, KY Park, PM Keegan, MO Platt Archives of biochemistry and biophysics 516 (1), 52-57, 2011 | 69 | 2011 |
Detection of femtomole quantities of mature cathepsin K with zymography WA Li, ZT Barry, JD Cohen, CL Wilder, RJ Deeds, PM Keegan, MO Platt Analytical biochemistry 401 (1), 91-98, 2010 | 50 | 2010 |
Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells PM Keegan, S Surapaneni, MO Platt Anemia 2012, 2012 | 44 | 2012 |
Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte–endothelial cell signaling and JNK activation PM Keegan, CL Wilder, MO Platt Molecular and cellular biochemistry 367, 65-72, 2012 | 41 | 2012 |
A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions MT Rogers, AL Gard, R Gaibler, TJ Mulhern, R Strelnikov, H Azizgolshani, ... Scientific reports 11 (1), 12225, 2021 | 33 | 2021 |
A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions SS Bale, A Manoppo, R Thompson, A Markoski, J Coppeta, B Cain, ... Biotechnology and Bioengineering 116 (12), 3409-3420, 2019 | 16 | 2019 |
Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions K Tan, J Coppeta, H Azizgolshani, BC Isenberg, PM Keegan, BP Cain, ... Lab on a Chip 20 (19), 3653-3653, 2020 | 8 | 2020 |
Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB PM Keegan, S Anbazhakan, B Kang, BS Pace, MO Platt Biological chemistry 397 (5), 459-468, 2016 | 8 | 2016 |
Low-cost method to monitor patient adherence to HIV antiretroviral therapy using multiplex cathepsin zymography MO Platt, D Evans, PM Keegan, L McNamara, IK Parker, LDM Roberts, ... Molecular biotechnology 58, 56-64, 2016 | 8 | 2016 |
Sickle cell anemia mediates carotid artery expansive remodeling that can be prevented by inhibition of JNK (c-Jun N-Terminal Kinase) H Song, PM Keegan, S Anbazhakan, CP Rivera, Y Feng, VO Omojola, ... Arteriosclerosis, thrombosis, and vascular biology 40 (5), 1220-1230, 2020 | 7 | 2020 |
Experimental and imaging techniques for examining fibrin clot structures in normal and diseased states NK Fan, PM Keegan, MO Platt, RD Averett JoVE (Journal of Visualized Experiments), e52019, 2015 | 7 | 2015 |
A platform to reproducibly evaluate human colon permeability and damage EE Marr, TJ Mulhern, M Welch, P Keegan, C Caballero-Franco, ... Scientific Reports 13 (1), 8922, 2023 | 3 | 2023 |
A high‐throughput microfluidic microphysiological system (PREDICT‐96) to recapitulate hepatocyte function in dynamic flow conditions K Tan, P Keegan, M Rogers, M Lu, J Gosset, J Charest, SS Bale The FASEB Journal 33 (S1), 508.1-508.1, 2019 | | 2019 |
Elastic lamina fragmentation in sickle mice can be rescued by JNK‐Cathepsin inhibition H Song, PM Keegan, AJ Denby, A Clark, J Selma, S Anbazhakan, ... The FASEB Journal 32, 676.13-676.13, 2018 | | 2018 |
Behavior Targeting Based on Hierarchical Taxonomy Aggregation for Heterogeneous Online Shopping Applications L ZHANG, C ZHANG, Z HU, X TANG ZTE Communications 16 (1), 52, 2018 | | 2018 |
A Complex Model for Studying Human Vascular Disease in a High-Throughput Microfluidic Platform N Raustad, M Rogers, A Gard, M Lech, P Keegan, C Williams TISSUE ENGINEERING PART A 23, S153-S153, 2017 | | 2017 |
Shear stress, hemodynamics, and proteolytic mechanisms underlying large artery remodeling in sickle cell disease PM Keegan Georgia Institute of Technology, 2014 | | 2014 |