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Philip Keegan
Philip Keegan
Adresse e-mail validée de gatech.edu
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High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows
H Azizgolshani, JR Coppeta, EM Vedula, EE Marr, BP Cain, RJ Luu, ...
Lab on a Chip 21 (8), 1454-1474, 2021
1222021
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD
AO Awojoodu, PM Keegan, AR Lane, Y Zhang, KR Lynch, MO Platt, ...
Blood, The Journal of the American Society of Hematology 124 (12), 1941-1950, 2014
922014
A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions
K Tan, P Keegan, M Rogers, M Lu, JR Gosset, J Charest, SS Bale
Lab on a Chip 19 (9), 1556-1566, 2019
772019
Manipulating substrate and pH in zymography protocols selectively distinguishes cathepsins K, L, S, and V activity in cells and tissues
CL Wilder, KY Park, PM Keegan, MO Platt
Archives of biochemistry and biophysics 516 (1), 52-57, 2011
692011
Detection of femtomole quantities of mature cathepsin K with zymography
WA Li, ZT Barry, JD Cohen, CL Wilder, RJ Deeds, PM Keegan, MO Platt
Analytical biochemistry 401 (1), 91-98, 2010
502010
Sickle cell disease activates peripheral blood mononuclear cells to induce cathepsins k and v activity in endothelial cells
PM Keegan, S Surapaneni, MO Platt
Anemia 2012, 2012
442012
Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte–endothelial cell signaling and JNK activation
PM Keegan, CL Wilder, MO Platt
Molecular and cellular biochemistry 367, 65-72, 2012
412012
A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions
MT Rogers, AL Gard, R Gaibler, TJ Mulhern, R Strelnikov, H Azizgolshani, ...
Scientific reports 11 (1), 12225, 2021
332021
A thermoplastic microfluidic microphysiological system to recapitulate hepatic function and multicellular interactions
SS Bale, A Manoppo, R Thompson, A Markoski, J Coppeta, B Cain, ...
Biotechnology and Bioengineering 116 (12), 3409-3420, 2019
162019
Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions
K Tan, J Coppeta, H Azizgolshani, BC Isenberg, PM Keegan, BP Cain, ...
Lab on a Chip 20 (19), 3653-3653, 2020
82020
Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB
PM Keegan, S Anbazhakan, B Kang, BS Pace, MO Platt
Biological chemistry 397 (5), 459-468, 2016
82016
Low-cost method to monitor patient adherence to HIV antiretroviral therapy using multiplex cathepsin zymography
MO Platt, D Evans, PM Keegan, L McNamara, IK Parker, LDM Roberts, ...
Molecular biotechnology 58, 56-64, 2016
82016
Sickle cell anemia mediates carotid artery expansive remodeling that can be prevented by inhibition of JNK (c-Jun N-Terminal Kinase)
H Song, PM Keegan, S Anbazhakan, CP Rivera, Y Feng, VO Omojola, ...
Arteriosclerosis, thrombosis, and vascular biology 40 (5), 1220-1230, 2020
72020
Experimental and imaging techniques for examining fibrin clot structures in normal and diseased states
NK Fan, PM Keegan, MO Platt, RD Averett
JoVE (Journal of Visualized Experiments), e52019, 2015
72015
A platform to reproducibly evaluate human colon permeability and damage
EE Marr, TJ Mulhern, M Welch, P Keegan, C Caballero-Franco, ...
Scientific Reports 13 (1), 8922, 2023
32023
A high‐throughput microfluidic microphysiological system (PREDICT‐96) to recapitulate hepatocyte function in dynamic flow conditions
K Tan, P Keegan, M Rogers, M Lu, J Gosset, J Charest, SS Bale
The FASEB Journal 33 (S1), 508.1-508.1, 2019
2019
Elastic lamina fragmentation in sickle mice can be rescued by JNK‐Cathepsin inhibition
H Song, PM Keegan, AJ Denby, A Clark, J Selma, S Anbazhakan, ...
The FASEB Journal 32, 676.13-676.13, 2018
2018
Behavior Targeting Based on Hierarchical Taxonomy Aggregation for Heterogeneous Online Shopping Applications
L ZHANG, C ZHANG, Z HU, X TANG
ZTE Communications 16 (1), 52, 2018
2018
A Complex Model for Studying Human Vascular Disease in a High-Throughput Microfluidic Platform
N Raustad, M Rogers, A Gard, M Lech, P Keegan, C Williams
TISSUE ENGINEERING PART A 23, S153-S153, 2017
2017
Shear stress, hemodynamics, and proteolytic mechanisms underlying large artery remodeling in sickle cell disease
PM Keegan
Georgia Institute of Technology, 2014
2014
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