Tobias Krojer
Tobias Krojer
Structural Genomics Consortium
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Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
T Krojer, M Garrido-Franco, R Huber, M Ehrmann, T Clausen
Nature 416 (6879), 455, 2002
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
T Krojer, M Garrido-Franco, R Huber, M Ehrmann, T Clausen
Nature 416 (6879), 455, 2002
Structural basis for the regulated protease and chaperone function of DegP
T Krojer, J Sawa, E Schäfer, HR Saibil, M Ehrmann, T Clausen
Nature 453 (7197), 885, 2008
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ...
Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ...
Journal of Biological Chemistry 288 (11), 7803-7814, 2013
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins
T Krojer, K Pangerl, J Kurt, J Sawa, C Stingl, K Mechtler, R Huber, ...
Proceedings of the National Academy of Sciences 105 (22), 7702-7707, 2008
5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation
RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ...
Chemical science 4 (8), 3110-3117, 2013
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues
T Krojer, J Sawa, R Huber, T Clausen
Nature Structural and Molecular Biology 17 (7), 844, 2010
Substrate-induced remodeling of the active site regulates human HTRA1 activity
L Truebestein, A Tennstaedt, T Mönig, T Krojer, F Canellas, M Kaiser, ...
Nature Structural and Molecular Biology 18 (3), 386, 2011
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
NR Rose, ECY Woon, A Tumber, LJ Walport, R Chowdhury, XS Li, ...
Journal of medicinal chemistry 55 (14), 6639-6643, 2012
Regulation of the σE stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals …
H Hasselblatt, R Kurzbauer, C Wilken, T Krojer, J Sawa, J Kurt, R Kirk, ...
Genes & development 21 (20), 2659-2670, 2007
Ribosomal oxygenases are structurally conserved from prokaryotes to humans
R Chowdhury, NC Brissett, T Krojer, C Ho, SS Ng, IJ Clifton, W Ge, ...
Nature 510 (7505), 422, 2014
Crystal structure of the 2-oxoglutarate-and Fe (II)-dependent lysyl hydroxylase JMJD6
M Mantri, T Krojer, EA Bagg, CJ Webby, DS Butler, G Kochan, ...
Journal of molecular biology 401 (2), 211-222, 2010
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8, 15123, 2017
Structural and mechanistic studies on γ-butyrobetaine hydroxylase
IKH Leung, TJ Krojer, GT Kochan, L Henry, F von Delft, TDW Claridge, ...
Chemistry & biology 17 (12), 1316-1324, 2010
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP (2), an atypical bromodomain
OB Cox, T Krojer, P Collins, O Monteiro, R Talon, A Bradley, O Fedorov, ...
Chemical Science 7 (3), 2322-2330, 2016
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli
M Meltzer, S Hasenbein, N Mamant, M Merdanovic, S Poepsel, P Hauske, ...
Research in microbiology 160 (9), 660-666, 2009
Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control
M Meltzer, S Hasenbein, P Hauske, N Kucz, M Merdanovic, S Grau, A Beil, ...
Angewandte Chemie International Edition 47 (7), 1332-1334, 2008
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors
V Bavetsias, RM Lanigan, GF Ruda, B Atrash, MG McLaughlin, A Tumber, ...
Journal of medicinal chemistry 59 (4), 1388-1409, 2016
Molecular adaptation of the DegQ protease to exert protein quality control in the bacterial cell envelope
J Sawa, H Malet, T Krojer, F Canellas, M Ehrmann, T Clausen
Journal of Biological Chemistry 286 (35), 30680-30690, 2011
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