Nicholas M Pearce
TitreCitée parAnnée
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8, 15123, 2017
552017
Gentle, fast and effective crystal soaking by acoustic dispensing
PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017
242017
The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination
T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017
242017
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
DA Keedy, ZB Hill, JT Biel, E Kang, TJ Rettenmaier, J Brandao-Neto, ...
Elife 7, e36307, 2018
202018
Proper modelling of ligand binding requires an ensemble of bound and unbound states
NM Pearce, T Krojer, F von Delft
Acta Crystallographica Section D: Structural Biology 73 (3), 256-266, 2017
132017
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites
NM Pearce, AR Bradley, T Krojer, BD Marsden, CM Deane, F Von Delft
Structural Dynamics 4 (3), 032104, 2017
52017
Ten simple rules for surviving an interdisciplinary PhD
S Demharter, N Pearce, K Beattie, I Frost, J Leem, A Martin, ...
PLoS computational biology 13 (5), e1005512, 2017
32017
Insights into enhanced complement activation by structures of properdin and its complex with the C-terminal domain of C3b
P Gros, V Den Bos, R Marijs, NM Pearce, J Granneman, HC Brondijk
Frontiers in immunology 10, 2097, 2019
2019
PANDDAs: multi-dataset methods for finding hits from fragment screening by X-ray crystallography
NM Pearce, S Kelm, J Shi, CM Deane, F von Delft
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 71, S258-S258, 2015
2015
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