Nicholas M Pearce
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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ...
Nature communications 8 (1), 1-8, 2017
712017
Gentle, fast and effective crystal soaking by acoustic dispensing
PM Collins, JT Ng, R Talon, K Nekrosiute, T Krojer, A Douangamath, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 246-255, 2017
332017
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
DA Keedy, ZB Hill, JT Biel, E Kang, TJ Rettenmaier, J Brandao-Neto, ...
Elife 7, e36307, 2018
322018
The XChemExplorer graphical workflow tool for routine or large-scale protein–ligand structure determination
T Krojer, R Talon, N Pearce, P Collins, A Douangamath, J Brandao-Neto, ...
Acta Crystallographica Section D: Structural Biology 73 (3), 267-278, 2017
302017
Proper modelling of ligand binding requires an ensemble of bound and unbound states
NM Pearce, T Krojer, F Von Delft
Acta Crystallographica Section D: Structural Biology 73 (3), 256-266, 2017
212017
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites
NM Pearce, AR Bradley, T Krojer, BD Marsden, CM Deane, F Von Delft
Structural Dynamics 4 (3), 032104, 2017
92017
Insights into enhanced complement activation by structures of properdin and its complex with the C-Terminal domain of C3b
P Gros, V Den Bos, R Marijs, NM Pearce, J Granneman, HC Brondijk
Frontiers in Immunology 10, 2097, 2019
42019
Ten simple rules for surviving an interdisciplinary PhD
S Demharter, N Pearce, K Beattie, I Frost, J Leem, A Martin, ...
PLOS Computational Biology 13 (5), e1005512, 2017
42017
Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F
W Oosterheert, KT Xenaki, V Neviani, W Pos, S Doulkeridou, ...
bioRxiv, 2020
2020
Rubies in the Smoke: Multi-dataset methods for the extraction of weak signal in X-ray crystallography
N Pearce, S Kelm, J Shi, C Deane, F von Delft
66th Annual Meeting, 2016
2016
PANDDAs: multi-dataset methods for finding hits from fragment screening by X-ray crystallography
NM Pearce, S Kelm, J Shi, CM Deane, F von Delft
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 71, S258-S258, 2015
2015
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