| Mapping the human genetic architecture of COVID-19 Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ... Nature 600 (7889), 472-477, 2021 | 720 | 2021 |
| PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo K Klein, M Thomas, S Winter, AK Nussler, M Niemi, M Schwab, ... Clinical Pharmacology & Therapeutics 91 (6), 1044-1052, 2012 | 169 | 2012 |
| BMP-9 interferes with liver regeneration and promotes liver fibrosis K Breitkopf-Heinlein, C Meyer, C König, H Gaitantzi, A Addante, ... Gut 66 (5), 939-954, 2017 | 129 | 2017 |
| Direct Transcriptional Regulation of Human Hepatic Cytochrome P450 3A4 (CYP3A4) by Peroxisome Proliferator-Activated Receptor Alpha (PPARα) M Thomas, O Burk, B Klumpp, BA Kandel, G Damm, TS Weiss, K Klein, ... Molecular Pharmacology, 2013 | 116 | 2013 |
| Comparative analysis of 3D culture methods on human HepG2 cells C Luckert, C Schulz, N Lehmann, M Thomas, U Hofmann, S Hammad, ... Archives of toxicology 91, 393-406, 2017 | 115 | 2017 |
| Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t (4; 11)-positive human leukemic cells M Thomas, A Geßner, HP Vornlocher, P Hadwiger, J Greil, O Heidenreich Blood 106 (10), 3559-3566, 2005 | 114 | 2005 |
| Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained G Kungulovski, S Nunna, M Thomas, UM Zanger, R Reinhardt, A Jeltsch Epigenetics & chromatin 8, 1-11, 2015 | 112 | 2015 |
| Genetics, epigenetics, and regulation of drug‐metabolizing cytochrome P450 enzymes UM Zanger, K Klein, M Thomas, JK Rieger, R Tremmel, BA Kandel, ... Clinical Pharmacology & Therapeutics 95 (3), 258-261, 2014 | 108 | 2014 |
| Different oxidative stress response in keratinocytes and fibroblasts of reconstructed skin exposed to non extreme daily-ultraviolet radiation C Marionnet, C Pierrard, F Lejeune, J Sok, M Thomas, F Bernerd PloS one 5 (8), e12059, 2010 | 108 | 2010 |
| A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes … M Klein, M Thomas, U Hofmann, D Seehofer, G Damm, UM Zanger Drug Metabolism and Disposition 43 (2), 273-283, 2015 | 96 | 2015 |
| TGF-β1 and TGF-β2 abundance in liver diseases of mice and men A Dropmann, T Dediulia, K Breitkopf-Heinlein, H Korhonen, M Janicot, ... Oncotarget 7 (15), 19499, 2016 | 80 | 2016 |
| Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes BA Kandel, M Thomas, S Winter, G Damm, D Seehofer, O Burk, ... Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1859 (9 …, 2016 | 71 | 2016 |
| Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice K Abshagen, M König, A Hoppe, I Müller, M Ebert, H Weng, HG Holzhütter, ... BMC systems biology 9, 1-21, 2015 | 69 | 2015 |
| IL-1β and TNFα differentially influence NF-κB activity and FasL-induced apoptosis in primary murine hepatocytes during LPS-induced inflammation J Rex, A Lutz, LE Faletti, U Albrecht, M Thomas, JG Bode, C Borner, ... Frontiers in physiology 10, 117, 2019 | 60 | 2019 |
| Impact of FLT3 mutations and secondary cytogenetic changes on the outcome of patients with newly diagnosed acute promyelocytic leukemia treated with a single agent arsenic … V Mathews, M Thomas, VM Srivastava, B George, A Srivastava, ... Haematologica 92 (7), 994-995, 2007 | 55 | 2007 |
| Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT A Gessner, M Thomas, P Garrido Castro, L Büchler, A Scholz, ... Leukemia 24 (10), 1751-1759, 2010 | 48 | 2010 |
| Model-based characterization of inflammatory gene expression patterns of activated macrophages J Rex, U Albrecht, C Ehlting, M Thomas, UM Zanger, O Sawodny, ... PLoS computational biology 12 (7), e1005018, 2016 | 43 | 2016 |
| Activating and inhibitory functions of WNT/β-catenin in the induction of cytochromes P450 by nuclear receptors in HepaRG cells M Thomas, C Bayha, S Vetter, U Hofmann, M Schwarz, UM Zanger, ... Molecular Pharmacology 87 (6), 1013-1020, 2015 | 42 | 2015 |
| Targeting leukemic fusion proteins with small interfering RNAs: recent advances and therapeutic potentials1 M Thomas, J Greil, O Heidenreich Acta Pharmacologica Sinica 27 (3), 273-281, 2006 | 41 | 2006 |
| Regulation of drug metabolism by the interplay of inflammatory signaling, steatosis, and xeno-sensing receptors in HepaRG cells N Tanner, L Kubik, C Luckert, M Thomas, U Hofmann, UM Zanger, ... Drug Metabolism and Disposition 46 (4), 326-335, 2018 | 37 | 2018 |
Ulrich M ZangerProfessor of Biochemical Pharmacology, Dr. Margarete Fischer-Bosch-Institute of ClinicalAdresse e-mail validée de ikp-stuttgart.de
