| Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases WS Aik, MA McDonough, A Thalhammer, R Chowdhury, CJ Schofield Current opinion in structural biology 22 (6), 691-700, 2012 | 206 | 2012 |
| Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation WS Aik, JS Scotti, H Choi, L Gong, M Demetriades, CJ Schofield, ... Nucleic acids research 42 (7), 4741-4754, 2014 | 188 | 2014 |
| Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation C Xu, K Liu, W Tempel, M Demetriades, WS Aik, CJ Schofield, J Min Journal of Biological Chemistry 289 (25), 17299-17311, 2014 | 183 | 2014 |
| 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation RJ Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, KH Che, XS Li, ... Chemical science 4 (8), 3110-3117, 2013 | 174 | 2013 |
| Structural basis for inhibition of the fat mass and obesity associated protein (FTO) WS Aik, M Demetriades, MKK Hamdan, EAL Bagg, KK Yeoh, C Lejeune, ... Journal of medicinal chemistry 56 (9), 3680-3688, 2013 | 151 | 2013 |
| Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition J Brem, SS Van Berkel, WS Aik, AM Rydzik, MB Avison, I Pettinati, ... Nature chemistry 6 (12), 1084-1090, 2014 | 134 | 2014 |
| Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir HS Lo, KPY Hui, HM Lai, X He, KS Khan, S Kaur, J Huang, Z Li, ... ACS central science 7 (5), 792-802, 2021 | 80 | 2021 |
| Structure of an active human histone pre-mRNA 3′-end processing machinery Y Sun, Y Zhang, WS Aik, XC Yang, WF Marzluff, T Walz, Z Dominski, ... Science 367 (6478), 700-703, 2020 | 79 | 2020 |
| Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation JS Scotti, IKH Leung, W Ge, MA Bentley, J Paps, HB Kramer, J Lee, ... Proceedings of the National Academy of Sciences 111 (37), 13331-13336, 2014 | 67 | 2014 |
| Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase ECY Woon, M Demetriades, EAL Bagg, WS Aik, SM Krylova, JHY Ma, ... Journal of medicinal chemistry 55 (5), 2173-2184, 2012 | 60 | 2012 |
| Pharmacological inhibition of FTO F McMurray, M Demetriades, WS Aik, M Merkestein, H Kramer, ... PLoS One 10 (4), e0121829, 2015 | 38 | 2015 |
| Structure of the ribosomal oxygenase OGFOD1 provides insights into the regio-and stereoselectivity of prolyl hydroxylases S Horita, JS Scotti, C Thinnes, YS Mottaghi-Taromsari, A Thalhammer, ... Structure 23 (4), 639-652, 2015 | 37 | 2015 |
| Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes. In 2-oxoglutarate-dependent oxygenases WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ... R. Soc. Chem. Cambridge, 59-94, 2015 | 36 | 2015 |
| Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes S Kaur, NY Tam, MA McDonough, CJ Schofield, WS Aik Nucleic Acids Research 50 (7), 4148-4160, 2022 | 32 | 2022 |
| Introduction to structural studies on 2-oxoglutarate-dependent oxygenases and related enzymes WS Aik, R Chowdhury, IJ Clifton, RJ Hopkinson, T Leissing, ... | 31 | 2015 |
| Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction Y Wu, WS Tam, HF Chau, S Kaur, W Thor, WS Aik, WL Chan, ... Chemical Science 11 (41), 11266-11273, 2020 | 20 | 2020 |
| Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5′–3′ exonuclease X Yang, Y Sun, WS Aik, WF Marzluff, L Tong, Z Dominski Rna 26 (10), 1345-1359, 2020 | 19 | 2020 |
| The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets A Thalhammer, WS Aik, EAL Bagg, CJ Schofield Drug Discovery Today: Therapeutic Strategies 9 (2-3), e91-e100, 2012 | 15 | 2012 |
| Composition and processing activity of a semi-recombinant holo U7 snRNP K Bucholc, WS Aik, X Yang, K Wang, ZH Zhou, M Dadlez, WF Marzluff, ... Nucleic acids research 48 (3), 1508-1530, 2020 | 13 | 2020 |
| The N-terminal domains of FLASH and Lsm11 form a 2: 1 heterotrimer for histone pre-mRNA 3’-end processing WS Aik, MH Lin, D Tan, A Tripathy, WF Marzluff, Z Dominski, CY Chou, ... PLoS One 12 (10), e0186034, 2017 | 12 | 2017 |
