| Efficient initiation of HCV RNA replication in cell culture KJ Blight, AA Kolykhalov, CM Rice Science 290 (5498), 1972-1974, 2000 | 1850 | 2000 |
| An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice TP Sheahan, AC Sims, S Zhou, RL Graham, AJ Pruijssers, ML Agostini, ... Science translational medicine 12 (541), eabb5883, 2020 | 1087 | 2020 |
| Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA AA Kolykhalov, EV Agapov, KJ Blight, K Mihalik, SM Feinstone, CM Rice Science 277 (5325), 570-574, 1997 | 919 | 1997 |
| Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo AA Kolykhalov, K Mihalik, SM Feinstone, CM Rice Journal of virology 74 (4), 2046-2051, 2000 | 845 | 2000 |
| Identification of a highly conserved sequence element at the 3'terminus of hepatitis C virus genome RNA AA Kolykhalov, SM Feinstone, CM Rice Journal of virology 70 (6), 3363-3371, 1996 | 636 | 1996 |
| SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 A Wahl, LE Gralinski, CE Johnson, W Yao, M Kovarova, KH Dinnon III, ... Nature 591 (7850), 451-457, 2021 | 380 | 2021 |
| Small-Molecule Antiviral β-d-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance ML Agostini, AJ Pruijssers, JD Chappell, J Gribble, X Lu, EL Andres, ... Journal of virology 93 (24), 10.1128/jvi. 01348-19, 2019 | 308 | 2019 |
| Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia M Toots, JJ Yoon, RM Cox, M Hart, ZM Sticher, N Makhsous, R Plesker, ... Science translational medicine 11 (515), eaax5866, 2019 | 303 | 2019 |
| Orally efficacious broad-spectrum ribonucleoside analog inhibitor of influenza and respiratory syncytial viruses JJ Yoon, M Toots, S Lee, ME Lee, B Ludeke, JM Luczo, K Ganti, RM Cox, ... Antimicrobial agents and chemotherapy 62 (8), 10.1128/aac. 00766-18, 2018 | 210 | 2018 |
| β-d-N4-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome N Urakova, V Kuznetsova, DK Crossman, A Sokratian, DB Guthrie, ... Journal of virology 92 (3), 10.1128/jvi. 01965-17, 2018 | 192 | 2018 |
| Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus ME Major, K Mihalik, J Fernandez, J Seidman, D Kleiner, AA Kolykhalov, ... Journal of virology 73 (4), 3317-3325, 1999 | 192 | 1999 |
| Specificity of the hepatitis C virus NS3 serine protease: effects of substitutions at the 3/4A, 4A/4B, 4B/5A, and 5A/5B cleavage sites on polyprotein processing AA Kolykhalov, EV Agapov, CM Rice Journal of Virology 68 (11), 7525-7533, 1994 | 173 | 1994 |
| Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus C McGuigan, K Madela, M Aljarah, A Gilles, A Brancale, N Zonta, ... Bioorganic & medicinal chemistry letters 20 (16), 4850-4854, 2010 | 143 | 2010 |
| The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection GR Painter, RA Bowen, GR Bluemling, J DeBergh, V Edpuganti, ... Antiviral research 171, 104597, 2019 | 113 | 2019 |
| INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent … JH Vernachio, B Bleiman, KD Bryant, S Chamberlain, D Hunley, ... Antimicrobial agents and chemotherapy 55 (5), 1843-1851, 2011 | 91 | 2011 |
| Phosphoramidate ProTides of 2′-C-Methylguanosine as Highly Potent Inhibitors of Hepatitis C Virus. Study of Their in Vitro and in Vivo Properties C McGuigan, A Gilles, K Madela, M Aljarah, S Holl, S Jones, J Vernachio, ... Journal of medicinal chemistry 53 (13), 4949-4957, 2010 | 89 | 2010 |
| Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets. KJ Blight, AA Kolykhalov, KE Reed, EV Agapov, CM Rice Antiviral therapy 3 (Suppl 3), 71-81, 1998 | 77 | 1998 |
| Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents C McGuigan, K Madela, M Aljarah, C Bourdin, M Arrica, E Barrett, S Jones, ... Journal of medicinal chemistry 54 (24), 8632-8645, 2011 | 70 | 2011 |
| Safe, long-term hepatic expression of anti-HCV shRNA in a nonhuman primate model DA Suhy, SC Kao, T Mao, L Whiteley, H Denise, B Souberbielle, ... Molecular Therapy 20 (9), 1737-1749, 2012 | 68 | 2012 |
| Functional DNA clone for hepatitis C virus (HCV) and uses thereof CM Rice, AA Kolykhalov US Patent 6,127,116, 2000 | 66 | 2000 |
Ilya FrolovVerified email at uab.edu
