Jay T. Goodwin
Jay T. Goodwin
Department of Chemistry, Emory University
Adresse e-mail validée de emory.edu
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Influence of molecular flexibility and polar surface area metrics on oral bioavailability in the rat
JJ Lu, K Crimin, JT Goodwin, P Crivori, C Orrenius, L Xing, PJ Tandler, ...
Journal of medicinal chemistry 47 (24), 6104-6107, 2004
1662004
Template-directed synthesis: use of a reversible reaction
JT Goodwin, DG Lynn
Journal of the American Chemical Society 114 (23), 9197-9198, 1992
1601992
In silico predictions of blood-brain barrier penetration: considerations to “keep in mind”
JT Goodwin, DE Clark
Journal of Pharmacology and Experimental Therapeutics 315 (2), 477-483, 2005
1252005
Physicochemical determinants of passive membrane permeability: role of solute hydrogen-bonding potential and volume
JT Goodwin, RA Conradi, NFH Ho, PS Burton
Journal of medicinal chemistry 44 (22), 3721-3729, 2001
1132001
Predicting drug absorption: how nature made it a difficult problem
PS Burton, JT Goodwin, TJ Vidmar, BM Amore
Journal of Pharmacology and Experimental Therapeutics 303 (3), 889-895, 2002
1052002
Characterization of the Fusarium toxin equisetin: the use of phenylboronates in structure assignment
NJ Phillips, JT Goodwin, A Fraiman, RJ Cole, DG Lynn
Journal of the American Chemical Society 111 (21), 8223-8231, 1989
951989
Incorporation of alkylthiol chains at C-5 of deoxyuridine
JT Goodwin, GD Glick
Tetrahedron letters 34 (35), 5549-5552, 1993
631993
Design, Synthesis, and Analysis of Yeast tRNAPhe Analogs Possessing Intra- and Interhelical Disulfide Cross-Links
JT Goodwin, SE Osborne, EJ Scholle, GD Glick
Journal of the American Chemical Society 118 (22), 5207-5215, 1996
561996
Synthesis of a disulfide stabilized RNA hairpin
JT Goodwin, GD Glick
Tetrahedron letters 35 (11), 1647-1650, 1994
481994
Strategies toward predicting peptide cellular permeability from computed molecular descriptors
JT Goodwin, RA Conradi, PS Burton, B Mao, TJ Vidmar
The Journal of peptide research 53 (4), 355-369, 1999
441999
In vitro permeability of peptidomimetic drugs: the role of polarized efflux pathways as additional barriers to absorption
PS Burton, JT Goodwin, RA Conradi, NFH Ho, AR Hilgers
Advanced drug delivery reviews 23 (1-3), 143-156, 1997
431997
Digital and analog chemical evolution
JT Goodwin, AK Mehta, DG Lynn
Accounts of chemical research 45 (12), 2189-2199, 2012
422012
Design of multi-phase dynamic chemical networks
C Chen, J Tan, MC Hsieh, T Pan, JT Goodwin, AK Mehta, MA Grover, ...
Nature chemistry 9 (8), 799-804, 2017
372017
227 Views of RNA: Is RNA Unique in Its Chemical Isomer Space?
HJII Cleaves, M Meringer, J Goodwin
Astrobiology 15 (7), 538-558, 2015
272015
Synthesis of a disulfide cross-linked DNA triple helix
JT Goodwin, SE Osborne, PC Swanson, GD Glick
Tetrahedron letters 35 (26), 4527-4530, 1994
241994
Improved solid-phase synthesis of long oligoribonucleotides: application to tRNAPhe and tRNAGly
JT Goodwin, WA Stanick, GD Glick
The Journal of Organic Chemistry 59 (26), 7941-7943, 1994
221994
Probing the structure of an RNA tertiary unfolding transition state
EJ Maglott, JT Goodwin, GD Glick
Journal of the American Chemical Society 121 (32), 7461-7462, 1999
201999
An NMR study of conformations of substituted dipeptides in dodecylphosphocholine micelles: implications for drug transport
DA Kloosterman, JT Goodwin, PS Burton, RA Conradi, BJ Stockman, ...
Biopolymers: Original Research on Biomolecules 53 (5), 396-410, 2000
162000
One among millions: the chemical space of Nucleic Acid-like molecules
HJ Cleaves, C Butch, PB Burger, J Goodwin, M Meringer
Journal of chemical information and modeling 59 (10), 4266-4277, 2019
152019
Alternative Chemistries of Life - Empirical Approaches
JT Goodwin, DG Lynn
Emory University, Department of Chemistry, 2014
152014
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