Ashley Pike
Ashley Pike
Structural Genomics Consortium - University of Oxford
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Molecular basis of agonism and antagonism in the oestrogen receptor
AM Brzozowski, ACW Pike, Z Dauter, RE Hubbard, T Bonn, O Engström, ...
Nature 389 (6652), 753-758, 1997
Estrogen receptors: how do they signal and what are their targets
N Heldring, A Pike, S Andersson, J Matthews, G Cheng, J Hartman, ...
Physiological reviews 87 (3), 905-931, 2007
Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
ACW Pike, AM Brzozowski, RE Hubbard, T Bonn, AG Thorsell, ...
The EMBO journal 18 (17), 4608-4618, 1999
Structural insights into the mode of action of a pure antiestrogen
ACW Pike, AM Brzozowski, J Walton, RE Hubbard, AG Thorsell, YL Li, ...
Structure 9 (2), 145-153, 2001
Crystal structures of guinea-pig, goat and bovine α-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase
ACW Pike, K Brew, KR Acharya
Structure 4 (6), 691-703, 1996
Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states
CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ...
Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013
A structural biologist's view of the oestrogen receptor
ACW Pike, AM Brzozowski, RE Hubbard
The Journal of steroid biochemistry and molecular biology 74 (5), 261-268, 2000
Structure of human factor VIIa and its implications for the triggering of blood coagulation
ACW Pike, AM Brzozowski, SM Roberts, OH Olsen, E Persson
Proceedings of the National Academy of Sciences 96 (16), 8925-8930, 1999
Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp
PLoS biology 8 (7), 2010
Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor α
A Wärnmark, E Treuter, JÅ Gustafsson, RE Hubbard, AM Brzozowski, ...
Journal of Biological Chemistry 277 (24), 21862-21868, 2002
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
YY Dong, ACW Pike, A Mackenzie, C McClenaghan, P Aryal, L Dong, ...
Science 347 (6227), 1256-1259, 2015
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ...
Journal of Biological Chemistry 288 (11), 7803-7814, 2013
Activation segment dimerization: a mechanism for kinase autophosphorylation of non‐consensus sites
ACW Pike, P Rellos, FH Niesen, A Turnbull, AW Oliver, SA Parker, ...
The EMBO journal 27 (4), 704-714, 2008
Lessons learnt from structural studies of the oestrogen receptor
ACW Pike
Best Practice & Research Clinical Endocrinology & Metabolism 20 (1), 1-14, 2006
Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
HJ Dubbink, R Hersmus, CS Verma, HAGM van der Korput, ...
Molecular Endocrinology 18 (9), 2132-2150, 2004
Structure and regulation of the human Nek2 centrosomal kinase
P Rellos, FJ Ivins, JE Baxter, A Pike, TJ Nott, DM Parkinson, S Das, ...
Journal of Biological Chemistry 282 (9), 6833-6842, 2007
Structure and mechanism of the oestrogen receptor
EH Kong, ACW Pike, RE Hubbard
Biochemical Society Transactions 31 (1), 56-59, 2003
Structure of the human RECQ1 helicase reveals a putative strand-separation pin
ACW Pike, B Shrestha, V Popuri, N Burgess-Brown, L Muzzolini, ...
Proceedings of the National Academy of Sciences 106 (4), 1039-1044, 2009
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
M Grieben, ACW Pike, CA Shintre, E Venturi, S El-Ajouz, A Tessitore, ...
Nature structural & molecular biology 24 (2), 114-122, 2017
A structural basis for the interaction of urea with lysozyme
ACW Pike, KR Acharya
Protein Science 3 (4), 706-710, 1994
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