Suivre
Brent D. Butts
Brent D. Butts
Biomarker Lead (Assoc. Director) Translational Medicine Oncology Business Unit, Eli Lilly
Adresse e-mail validée de lilly.com
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Glycogen synthase kinase-3β phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
DA Linseman, BD Butts, TA Precht, RA Phelps, SS Le, TA Laessig, ...
Journal of Neuroscience 24 (44), 9993-10002, 2004
4782004
Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice
NB Hastings, X Wang, L Song, BD Butts, D Grotz, R Hargreaves, ...
Molecular Neurodegeneration 12, 1-16, 2017
1332017
Maturation-dependent sensitivity of oligodendrocyte lineage cells to apoptosis: implications for normal development and disease
BD Butts, C Houde, H Mehmet
Cell Death & Differentiation 15 (7), 1178-1186, 2008
1282008
The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis
TA Precht, RA Phelps, DA Linseman, BD Butts, SS Le, TA Laessig, ...
Cell Death & Differentiation 12 (3), 255-265, 2005
912005
Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression
A Gupta, B Butts, KA Kwei, K Dvorakova, SP Stratton, MM Briehl, ...
Cancer letters 173 (2), 115-125, 2001
912001
The genome of ε15, a serotype-converting, Group E1 Salmonella enterica-specific bacteriophage
AM Kropinski, IV Kovalyova, SJ Billington, AN Patrick, BD Butts, ...
Virology 369 (2), 234-244, 2007
762007
Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors
BD Butts, HR Hudson, DA Linseman, SS Le, KR Ryan, RJ Bouchard, ...
Molecular and Cellular Neuroscience 30 (2), 279-289, 2005
382005
Increased Tumor Necrosis Factor-a Sensitivity of MCF-7 Cells Transfected with NAD (P) H: Quinone Reductase
LM Siemankowski, J Morreale, BD Butts, MM Briehl
Cancer Research 60 (13), 3638-3644, 2000
362000
Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl‐2/Bcl‐x (L) versus induction of the BH3‐only protein Bim
AK Zimmermann, FA Loucks, SS Le, BD Butts, ML Florez‐McClure, ...
Journal of neurochemistry 94 (1), 22-36, 2005
282005
Identification of a functional peroxisome proliferator activated receptor response element in the 3'untranslated region of the human bcl-2 gene
BD Butts, NL Tran, MM Briehl
International journal of oncology 24 (5), 1305-1310, 2004
282004
Elevated basal reactive oxygen species and phospho‐Akt in murine keratinocytes resistant to ultraviolet B–induced apoptosis
BD Butts, KA Kwei, GT Bowden, MM Briehl
Molecular Carcinogenesis: Published in cooperation with the University of …, 2003
282003
Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes: a novel approach
X Ai, B Butts, K Vora, W Li, C Tache-Talmadge, A Fridman, H Mehmet
Cell death & disease 2 (9), e205-e205, 2011
212011
Insulin-like growth factor-I suppresses degradation of the pro-survival transcription factor myocyte enhancer factor 2D (MEF2D) during neuronal apoptosis
BD Butts, DA Linseman, SS Le, TA Laessig, KA Heidenreich
Hormone and metabolic research 35 (11/12), 763-770, 2003
162003
MerCASBA: an updated and refined database of caspase substrates
A Fridman, I Pak, BD Butts, M Hoek, DW Nicholson, H Mehmet
Apoptosis 18, 369-371, 2013
132013
The effects of house dust mite sublingual immunotherapy tablet on immunologic biomarkers and nasal allergen challenge symptoms
NC Gunawardana, Q Zhao, LN Carayannopoulos, K Tsai, VA Malkov, ...
Journal of Allergy and Clinical Immunology 141 (2), 785-788. e9, 2018
92018
Ramucirumab plus erlotinib versus placebo plus erlotinib in previously untreated EGFR-mutated metastatic non-small-cell lung cancer (RELAY): exploratory analysis of next …
EB Garon, M Reck, K Nishio, JV Heymach, M Nishio, S Novello, ...
ESMO open 8 (4), 101580, 2023
22023
Antitumor activity and safety of MK-1308 (anti-CTLA-4) plus pembrolizumab (pembro) in patients (pts) with non-small cell lung cancer (NSCLC): Updated interim results from a …
R Perets, K Yoh, DW Kim, J Bar, MJ Ahn, A Nagrial, M Satouchi, ...
Journal of Clinical Oncology 37 (15_suppl), 2558-2558, 2019
22019
Targeted quantitative mass spectrometry analysis of protein biomarkers from previously stained single formalin-fixed paraffin-embedded tissue sections
BL Ackermann, RD Morrison, S Hill, MD Westfall, BD Butts, MD Soper, ...
Laboratory Investigation 103 (4), 100052, 2023
12023
Caspases and cell death
LD Hernandez, C Houde, M Hoek, B Butts, DW Nicholson, H Mehmet
eLS, 2009
12009
Phase I study of the CTLA-4 inhibitor MK-1308 in combination with pembrolizumab in patients with advanced solid tumors
BC Cho, R Perets, J Bar, MJ Ahn, DW Kim, K Yoh, A Nagrial, DR Spigel, ...
Annals of Oncology 29, viii135, 2018
2018
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