A toxin-antidote CRISPR gene drive system for regional population modification J Champer, E Lee, E Yang, C Liu, AG Clark, PW Messer Nature communications 11 (1), 1082, 2020 | 105 | 2020 |
Molecular safeguarding of CRISPR gene drive experiments J Champer, J Chung, YL Lee, C Liu, E Yang, Z Wen, AG Clark, ... Elife 8, e41439, 2019 | 105 | 2019 |
A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population J Champer, E Yang, E Lee, J Liu, AG Clark, PW Messer Proceedings of the National Academy of Sciences 117 (39), 24377-24383, 2020 | 89 | 2020 |
CRISPR gene drive efficiency and resistance rate is highly heritable with no common genetic loci of large effect J Champer, Z Wen, A Luthra, R Reeves, J Chung, C Liu, YL Lee, J Liu, ... Genetics 212 (1), 333-341, 2019 | 37 | 2019 |
A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles E Yang, M Metzloff, AM Langmüller, X Xu, AG Clark, PW Messer, ... G3 12 (6), jkac081, 2022 | 34 | 2022 |
Experimental demonstration of tethered gene drive systems for confined population modification or suppression M Metzloff, E Yang, S Dhole, AG Clark, PW Messer, J Champer BMC biology 20 (1), 119, 2022 | 23 | 2022 |
Resistance is futile: A CRISPR homing gene drive targeting a haplolethal gene J Champer, E Yang, YL Lee, J Liu, AG Clark, PW Messer BioRxiv, 651737, 2019 | 9 | 2019 |
Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive J Champer, Z Wen, A Luthra, R Reeves, J Chung, C Liu, YL Lee, J Liu, ... bioRxiv, 447615, 2018 | 6 | 2018 |