Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations B Luan, H Wang, T Huynh FEBS letters 595 (10), 1454-1461, 2021 | 175 | 2021 |
In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease T Huynh, H Wang, B Luan The Journal of Physical Chemistry Letters 11 (11), 4413-4420, 2020 | 167 | 2020 |
Intersectin links WNK kinases to endocytosis of ROMK1 G He, HR Wang, SK Huang, CL Huang The Journal of clinical investigation 117 (4), 1078-1087, 2007 | 167 | 2007 |
Predicting functional effects of missense variants in voltage-gated sodium and calcium channels HO Heyne, D Baez-Nieto, S Iqbal, DS Palmer, A Brunklaus, P May, ... Science translational medicine 12 (556), eaay6848, 2020 | 126 | 2020 |
Selective Inhibition of the Kir2 Family of Inward Rectifier Potassium Channels by a Small Molecule Probe: The Discovery, SAR, and Pharmacological … HR Wang, M Wu, H Yu, S Long, A Stevens, DW Engers, H Sackin, ... ACS chemical biology 6 (8), 845-856, 2011 | 110 | 2011 |
Targeting proteases for treating COVID-19 B Luan, T Huynh, X Cheng, G Lan, HR Wang Journal of proteome research 19 (11), 4316-4326, 2020 | 101 | 2020 |
Biological concepts in human sodium channel epilepsies and their relevance in clinical practice A Brunklaus, J Du, F Steckler, II Ghanty, KM Johannesen, CD Fenger, ... Epilepsia 61 (3), 387-399, 2020 | 87 | 2020 |
Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase Z Liu, HR Wang, CL Huang Journal of Biological Chemistry 284 (18), 12198-12206, 2009 | 65 | 2009 |
WNKs: protein kinases with a unique kinase domain CL Huang, SK Cha, HR Wang, J Xie, MH Cobb Experimental & molecular medicine 39 (5), 565-573, 2007 | 65 | 2007 |
A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine H Guo, LM Camargo, F Yeboah, ME Digan, H Niu, Y Pan, S Reiling, ... Scientific reports 7 (1), 11608, 2017 | 55 | 2017 |
Molecular mechanism of the N501Y mutation for enhanced binding between SARS-CoV-2’s spike protein and human ACE2 receptor B Luan, H Wang, T Huynh BioRxiv, 2021.01. 04.425316, 2021 | 47 | 2021 |
Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters M Fine, FM Lu, MJ Lin, O Moe, HR Wang, DW Hilgemann American Journal of Physiology-Cell Physiology 305 (5), C481-C491, 2013 | 44 | 2013 |
Structure-based lead optimization of herbal medicine rutin for inhibiting SARS-CoV-2's main protease T Huynh, H Wang, B Luan Physical Chemistry Chemical Physics 22 (43), 25335-25343, 2020 | 41 | 2020 |
Domains of WNK1 kinase in the regulation of ROMK1 HR Wang, Z Liu, CL Huang American Journal of Physiology-Renal Physiology 295 (2), F438-F445, 2008 | 29 | 2008 |
Implications of dynamic occupancy, binding kinetics, and channel gating kinetics for hERG blocker safety assessment and mitigation R A Pearlstein, K Andrew MacCannell, G Erdemli, S Yeola, G Helmlinger, ... Current Topics in Medicinal Chemistry 16 (16), 1792-1818, 2016 | 27 | 2016 |
Structural characterization of novel comb-like branched α-D-glucan from Arca inflata and its immunoregulatory activities in vitro and in vivo C Li, D Peng, W Huang, X Ou, L Song, Z Guo, H Wang, W Liu, J Zhu, R Yu Food & function 10 (10), 6589-6603, 2019 | 21 | 2019 |
Developing high-throughput assays to analyze and screen electrophysiological phenotypes JQ Pan, D Baez-Nieto, A Allen, HR Wang, JR Cottrell Phenotypic screening: methods and protocols, 235-252, 2018 | 18 | 2018 |
In Silico exploration of repurposing and optimizing traditional Chinese medicine rutin for possibly inhibiting SARS-CoV-2's main protease T Huynh, H Wang, W Cornell, B Luan | 9 | 2020 |
Identification and Characterization of a Novel Protein ASP-3 Purified from Arca subcrenata and Its Antitumor Mechanism Z Guo, H Shi, C Li, Y Luo, S Bi, R Yu, H Wang, W Liu, J Zhu, W Huang, ... Marine drugs 17 (9), 528, 2019 | 9 | 2019 |
Differential sensitivity of Kir2 inward-rectifier potassium channels to a mitochondrial uncoupler: identification of a regulatory site A Collins, H Wang, MK Larson Molecular pharmacology 67 (4), 1214-1220, 2005 | 8 | 2005 |