Antibiotics: past, present and future MI Hutchings, AW Truman, B Wilkinson Current opinion in microbiology 51, 72-80, 2019 | 2148 | 2019 |
Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 903 | 2015 |
Drug discovery beyond the ‘rule-of-five’ MQ Zhang, B Wilkinson Current opinion in biotechnology 18 (6), 478-488, 2007 | 448 | 2007 |
Biosynthesis of erythromycin and rapamycin J Staunton, B Wilkinson Chemical reviews 97 (7), 2611-2630, 1997 | 350 | 1997 |
Engineering broader specificity into an antibiotic-producing polyketide synthase AFA Marsden, B Wilkinson, J Cortes, NJ Dunster, J Staunton, PF Leadlay Science 279 (5348), 199-202, 1998 | 334 | 1998 |
Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor Z Hojati, C Milne, B Harvey, L Gordon, M Borg, F Flett, B Wilkinson, ... Chemistry & biology 9 (11), 1175-1187, 2002 | 332 | 2002 |
Mining and engineering natural-product biosynthetic pathways B Wilkinson, J Micklefield Nature chemical biology 3 (7), 379-386, 2007 | 289 | 2007 |
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions C Olano, B Wilkinson, C Sánchez, SJ Moss, R Sheridan, V Math, ... Chemistry & Biology 11 (1), 87-97, 2004 | 207 | 2004 |
Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants Z Qin, JT Munnoch, R Devine, NA Holmes, RF Seipke, KA Wilkinson, ... Chemical science 8 (4), 3218-3227, 2017 | 171 | 2017 |
Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity SJ Moss, CJ Martin, B Wilkinson Natural product reports 21 (5), 575-593, 2004 | 169 | 2004 |
Active-site residue, domain and module swaps in modular polyketide synthases F Del Vecchio, H Petkovic, SG Kendrew, L Low, B Wilkinson, R Lill, ... Journal of Industrial Microbiology and Biotechnology 30 (8), 489-494, 2003 | 152 | 2003 |
Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues A Ranganathan, M Timoney, M Bycroft, J Cortés, IP Thomas, B Wilkinson, ... Chemistry & biology 6 (10), 731-741, 1999 | 152 | 1999 |
Tritiated Chiral Alkanes as Substrates for Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath): Probes for the Mechanism of Hydroxylation AM Valentine, B Wilkinson, KE Liu, S Komar-Panicucci, ND Priestley, ... Journal of the American Chemical Society 119 (8), 1818-1827, 1997 | 146 | 1997 |
Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis MA Gregory, H Petkovic, RE Lill, SJ Moss, B Wilkinson, S Gaisser, ... Angewandte Chemie International Edition 44 (30), 4757-4760, 2005 | 141 | 2005 |
Engineering a polyketide with a longer chain by insertion of an extra module into the erythromycin-producing polyketide synthase CJ Rowe, IU Böhm, IP Thomas, B Wilkinson, BAM Rudd, G Foster, ... Chemistry & biology 8 (5), 475-485, 2001 | 132 | 2001 |
Roles of rapH and rapG in Positive Regulation of Rapamycin Biosynthesis in Streptomyces hygroscopicus E Kuščer, N Coates, I Challis, M Gregory, B Wilkinson, R Sheridan, ... Journal of bacteriology 189 (13), 4756-4763, 2007 | 128 | 2007 |
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate JN Andexer, SG Kendrew, M Nur-e-Alam, O Lazos, TA Foster, ... Proceedings of the National Academy of Sciences 108 (12), 4776-4781, 2011 | 126 | 2011 |
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity D Hoffmeister, B Wilkinson, G Foster, PJ Sidebottom, K Ichinose, ... Chemistry & biology 9 (3), 287-295, 2002 | 121 | 2002 |
A Concerted Mechanism for Ethane Hydroxylation by the Particulate Methane Monooxygenase from Methylococcus capsulatus (Bath) B Wilkinson, M Zhu, ND Priestley, HHT Nguyen, H Morimoto, PG Williams, ... Journal of the American Chemical Society 118 (4), 921-922, 1996 | 120 | 1996 |
Combinatorial biosynthesis of polyketides and nonribosomal peptides J Staunton, B Wilkinson Current opinion in chemical biology 5 (2), 159-164, 2001 | 115 | 2001 |