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Malcolm Irving
Malcolm Irving
Adresse e-mail validée de kcl.ac.uk
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Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size
G Piazzesi, M Reconditi, M Linari, L Lucii, P Bianco, E Brunello, ...
Cell 131 (4), 784-795, 2007
3552007
Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments
M Linari, E Brunello, M Reconditi, L Fusi, M Caremani, T Narayanan, ...
Nature 528 (7581), 276-279, 2015
2812015
Myosin head movements are synchronous with the elementary force-generating process in muscle
M Irving, V Lombardi, G Piazzesi, MA Ferenczi
Nature 357 (6374), 156-158, 1992
2561992
Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction
JET Corrie, BD Brandmeier, RE Ferguson, DR Trentham, ...
Nature 400 (6743), 425-430, 1999
2471999
Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle
M Irving, T St Claire Alien, C Sabido-David, JS Craik, B Brandmeier, ...
Nature 375 (6533), 688-691, 1995
2361995
The myosin motor in muscle generates a smaller and slower working stroke at higher load
M Reconditi, M Linari, L Lucii, A Stewart, YB Sun, P Boesecke, ...
Nature 428 (6982), 578-581, 2004
2272004
The stiffness of skeletal muscle in isometric contraction and rigor: the fraction of myosin heads bound to actin
M Linari, I Dobbie, M Reconditi, N Koubassova, M Irving, G Piazzesi, ...
Biophysical journal 74 (5), 2459-2473, 1998
2121998
Elastic bending and active tilting of myosin heads during muscle contraction
I Dobbie, M Linari, G Piazzesi, M Reconditi, N Koubassova, MA Ferenczi, ...
Nature 396 (6709), 383-387, 1998
1911998
Mechanism of force generation by myosin heads in skeletal muscle
G Piazzesi, M Reconditi, M Linari, L Lucii, YB Sun, T Narayanan, ...
Nature 415 (6872), 659-662, 2002
1842002
Regulation of contraction by the thick filaments in skeletal muscle
M Irving
Biophysical journal 113 (12), 2579-2594, 2017
1572017
Elastic distortion of myosin heads and repriming of the working stroke in muscle
V Lombard, G Piazzesi, MA Ferenczi, H Thirlwell, I Dobbie, M Irving
Nature 374 (6522), 553-555, 1995
1431995
Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin
E Brunello, M Reconditi, R Elangovan, M Linari, YB Sun, T Narayanan, ...
Proceedings of the National Academy of Sciences 104 (50), 20114-20119, 2007
1342007
Conformation of the myosin motor during force generation in skeletal muscle
M Irving, G Piazzesi, L Lucii, YB Sun, JJ Harford, IM Dobbie, MA Ferenczi, ...
Nature structural biology 7 (6), 482-485, 2000
1312000
Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers
M Linari, G Piazzesi, I Dobbie, N Koubassova, M Reconditi, T Narayanan, ...
Proceedings of the National Academy of Sciences 97 (13), 7226-7231, 2000
1292000
Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments
T Kampourakis, YB Sun, M Irving
Proceedings of the National Academy of Sciences 113 (21), E3039-E3047, 2016
1272016
Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells
T Kampourakis, Z Yan, M Gautel, YB Sun, M Irving
Proceedings of the National Academy of Sciences 111 (52), 18763-18768, 2014
1272014
Calcium‐and myosin‐dependent changes in troponin structure during activation of heart muscle
YB Sun, F Lou, M Irving
The Journal of Physiology 587 (1), 155-163, 2009
1152009
Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
L Fusi, E Brunello, Z Yan, M Irving
Nature communications 7 (1), 13281, 2016
1082016
Fluorescence polarization transients from rhodamine isomers on the myosin regulatory light chain in skeletal muscle fibers
SC Hopkins, C Sabido-David, JET Corrie, M Irving, YE Goldman
Biophysical journal 74 (6), 3093-3110, 1998
1071998
Myosin filament-based regulation of the dynamics of contraction in heart muscle
E Brunello, L Fusi, A Ghisleni, SJ Park-Holohan, JG Ovejero, ...
Proceedings of the National Academy of Sciences 117 (14), 8177-8186, 2020
1002020
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