Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy Y Ichimura, S Waguri, Y Sou, S Kageyama, J Hasegawa, R Ishimura, ... Molecular cell 51 (5), 618-631, 2013 | 1069 | 2013 |
TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia K Naka, T Hoshii, T Muraguchi, Y Tadokoro, T Ooshio, Y Kondo, S Nakao, ... Nature 463 (7281), 676-680, 2010 | 697 | 2010 |
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ Y Kurebayashi, S Nagai, A Ikejiri, M Ohtani, K Ichiyama, Y Baba, ... Cell reports 1 (4), 360-373, 2012 | 355 | 2012 |
Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells K Naka, T Muraguchi, T Hoshii, A Hirao Antioxidants & redox signaling 10 (11), 1883-1894, 2008 | 282 | 2008 |
ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia L Wan, H Wen, Y Li, J Lyu, Y Xi, T Hoshii, JK Joseph, X Wang, YHE Loh, ... Nature 543 (7644), 265-269, 2017 | 241 | 2017 |
Metabolic regulation of osteoclast differentiation and function Y Indo, S Takeshita, KA Ishii, T Hoshii, H Aburatani, A Hirao, K Ikeda Journal of Bone and Mineral Research 28 (11), 2392-2399, 2013 | 230 | 2013 |
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ... Cancer discovery 6 (10), 1166-1181, 2016 | 208 | 2016 |
Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells T Takeo, T Hoshii, Y Kondo, H Toyodome, H Arima, K Yamamura, T Irie, ... Biology of reproduction 78 (3), 546-551, 2008 | 181 | 2008 |
mTORC1 is essential for leukemia propagation but not stem cell self-renewal T Hoshii, Y Tadokoro, K Naka, T Ooshio, T Muraguchi, N Sugiyama, ... The Journal of clinical investigation 122 (6), 2114-2129, 2012 | 150 | 2012 |
A non-catalytic function of SETD1A regulates cyclin K and the DNA damage response T Hoshii, P Cifani, Z Feng, CH Huang, R Koche, CW Chen, CD Delaney, ... Cell 172 (5), 1007-1021. e17, 2018 | 101 | 2018 |
Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin A Tamase, T Muraguchi, K Naka, S Tanaka, M Kinoshita, T Hoshii, ... Proceedings of the National Academy of Sciences 106 (40), 17163-17168, 2009 | 95 | 2009 |
LGR4 regulates the postnatal development and integrity of male reproductive tracts in mice T Hoshii, T Takeo, N Nakagata, M Takeya, K Araki, K Yamamura Biology of reproduction 76 (2), 303-313, 2007 | 90 | 2007 |
Defective development of the gall bladder and cystic duct in Lgr4‐ hypomorphic mice R Yamashita, Y Takegawa, M Sakumoto, M Nakahara, H Kawazu, ... Developmental Dynamics 238 (4), 993-1000, 2009 | 88 | 2009 |
Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production M Ohtani, T Hoshii, H Fujii, S Koyasu, A Hirao, S Matsuda The Journal of Immunology 188 (10), 4736-4740, 2012 | 86 | 2012 |
Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells K Naka, T Hoshii, A Hirao Cancer science 101 (7), 1577-1581, 2010 | 77 | 2010 |
Cross-species chromatin interactions drive transcriptional rewiring in Epstein–Barr virus–positive gastric adenocarcinoma A Okabe, KK Huang, K Matsusaka, M Fukuyo, M Xing, X Ong, T Hoshii, ... Nature Genetics 52 (9), 919-930, 2020 | 71 | 2020 |
Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells T Hoshii, A Kasada, T Hatakeyama, M Ohtani, Y Tadokoro, K Naka, ... Proceedings of the National Academy of Sciences 111 (10), 3805-3810, 2014 | 68 | 2014 |
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function T Imanishi, M Unno, W Kobayashi, N Yoneda, S Matsuda, K Ikeda, ... Life science alliance 2 (1), 2019 | 53 | 2019 |
Mixed-lineage leukemia fusions and chromatin in leukemia AV Krivtsov, T Hoshii, SA Armstrong Cold Spring Harbor Perspectives in Medicine 7 (11), a026658, 2017 | 53 | 2017 |
Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis DG Valerio, H Xu, CW Chen, T Hoshii, ME Eisold, C Delaney, M Cusan, ... Cancer research 77 (7), 1753-1762, 2017 | 50 | 2017 |