| Can the pharmaceutical industry reduce attrition rates? I Kola, J Landis Nature reviews Drug discovery 3 (8), 711-716, 2004 | 5020 | 2004 |
| BACE knockout mice are healthy despite lacking the primary β-secretase activity in brain: implications for Alzheimer’s disease therapeutics SL Roberds, J Anderson, G Basi, MJ Bienkowski, DG Branstetter, ... Human molecular genetics 10 (12), 1317-1324, 2001 | 982 | 2001 |
| Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization M Gowen, F Lazner, R Dodds, R Kapadia, J Feild, M Tavaria, I Bertoncello, ... Journal of bone and mineral research 14 (10), 1654-1663, 1999 | 621 | 1999 |
| Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and … JB de Haan, C Bladier, P Griffiths, M Kelner, RD O'Shea, NS Cheung, ... Journal of Biological Chemistry 273 (35), 22528-22536, 1998 | 597 | 1998 |
| A hitchhiker's guide to the human Hsp70 family M Tavaria, T Gabriele, I Kola, RL Anderson Cell stress & chaperones 1 (1), 23, 1996 | 582 | 1996 |
| A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters … SY Hwang, PJ Hertzog, KA Holland, SH Sumarsono, MJ Tymms, ... Proceedings of the National Academy of Sciences 92 (24), 11284-11288, 1995 | 492 | 1995 |
| The state of innovation in drug development I Kola Clinical Pharmacology & Therapeutics 83 (2), 227-230, 2008 | 335 | 2008 |
| Phenotypic characterization of an α4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse SA Ross, JYF Wong, JJ Clifford, A Kinsella, JS Massalas, MK Horne, ... Journal of Neuroscience 20 (17), 6431-6441, 2000 | 297 | 2000 |
| The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ … I Kola, S Brookes, AR Green, R Garber, M Tymms, TS Papas, A Seth Proceedings of the National Academy of Sciences 90 (16), 7588-7592, 1993 | 283 | 1993 |
| Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide JB De Haan, F Cristiano, R Iannello, C Bladier, MJ Kelner, I Kola Human molecular genetics 5 (2), 283-292, 1996 | 270 | 1996 |
| Centrioles in the beginning of human development. AH Sathananthan, I Kola, J Osborne, A Trounson, SC Ng, A Bongso, ... Proceedings of the National Academy of Sciences 88 (11), 4806-4810, 1991 | 268 | 1991 |
| Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E–deficient mice P Lewis, N Stefanovic, J Pete, AC Calkin, S Giunti, V Thallas-Bonke, ... Circulation 115 (16), 2178-2187, 2007 | 267 | 2007 |
| Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice S Heru Sumarsono, TJ Wilson, MJ Tymms, DJ Venter, CM Corrick, R Kola, ... Nature 379 (6565), 534-537, 1996 | 259 | 1996 |
| Increased infarct size and exacerbated apoptosis in the glutathione peroxidase‐1 (Gpx‐1) knockout mouse brain in response to ischemia/reperfusion injury PJ Crack, JM Taylor, NJ Flentjar, J De Haan, P Hertzog, RC Iannello, ... Journal of neurochemistry 78 (6), 1389-1399, 2001 | 256 | 2001 |
| Fertilization of human oocytes by microinjection of a single spermatozoon under the zona pellucida A Laws-King, A Trounson, H Sathananthan, I Kola Fertility and sterility 48 (4), 637-642, 1987 | 235 | 1987 |
| Response of a primary human fibroblast cell line to H2O2: senescence-like growth arrest or apoptosis? C Bladier, EJ Wolvetang, P Hutchinson, JB De Haan, I Kola Cell growth & differentiation: the molecular biology journal of the American …, 1997 | 230 | 1997 |
| Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium AYN Ng, P Waring, S Ristevski, C Wang, T Wilson, M Pritchard, P Hertzog, ... Gastroenterology 122 (5), 1455-1466, 2002 | 203 | 2002 |
| Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. JB De Haan, F Cristiano, RC Iannello, I Kola Biochemistry and molecular biology international 35 (6), 1281-1297, 1995 | 201 | 1995 |
| Tripronuclear human oocytes: altered cleavage patterns and subsequent karyotypic analysis of embryos I Kola, A Trounson, G Dawson, P Rogers Biology of reproduction 37 (2), 395-401, 1987 | 180 | 1987 |
| Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation J Zhou, R Chehab, J Tkalcevic, MJ Naylor, J Harris, TJ Wilson, S Tsao, ... The EMBO journal 24 (3), 635-644, 2005 | 176 | 2005 |
Paul J. HertzogHudson Institute of Medical ResearchVerified email at monash.edu
