Nicolas Gilles
Nicolas Gilles
reseacher CEA
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The differential preference of scorpion α-toxins for insect or mammalian sodium channels: implications for improved insect control
D Gordon, I Karbat, N Ilan, L Cohen, R Kahn, N Gilles, K Dong, ...
Toxicon 49 (4), 452-472, 2007
Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel
G Corzo, N Gilles, H Satake, E Villegas, L Dai, T Nakajima, J Haupt
FEBS letters 547 (1-3), 43-50, 2003
Molecular basis of the high insecticidal potency of scorpion α-toxins
I Karbat, F Frolow, O Froy, N Gilles, L Cohen, M Turkov, D Gordon, ...
Journal of Biological Chemistry 279 (30), 31679-31686, 2004
Common features in the functional surface of scorpion β-toxins and elements that confer specificity for insect and mammalian voltage-gated sodium channels
L Cohen, I Karbat, N Gilles, N Ilan, M Benveniste, D Gordon, M Gurevitz
Journal of Biological Chemistry 280 (6), 5045-5053, 2005
The putative bioactive surface of insect-selective scorpion excitatory neurotoxins
O Froy, N Zilberberg, D Gordon, M Turkov, N Gilles, M Stankiewicz, ...
Journal of Biological Chemistry 274 (9), 5769-5776, 1999
New method for characterizing highly disulfide-bridged peptides in complex mixtures: application to toxin identification from crude venoms
L Quinton, K Demeure, R Dobson, N Gilles, V Gabelica, E De Pauw
Journal of proteome research 6 (8), 3216-3223, 2007
NMR structures and activity of a novel α-like toxin from the scorpion Leiurus quinquestriatus hebraeus
I Krimm, N Gilles, P Sautière, M Stankiewicz, M Pelhate, D Gordon, ...
Journal of molecular biology 285 (4), 1749-1763, 1999
A δ-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles
J Barbier, H Lamthanh, F Le Gall, P Favreau, E Benoit, H Chen, N Gilles, ...
Journal of Biological Chemistry 279 (6), 4680-4685, 2004
Dissection of the functional surface of an anti-insect excitatory toxin illuminates a putative “hot spot” common to all scorpion β-toxins affecting Na+ channels
L Cohen, I Karbat, N Gilles, O Froy, G Corzo, R Angelovici, D Gordon, ...
Journal of Biological Chemistry 279 (9), 8206-8211, 2004
Exploration of the functional site of a scorpion α-like toxin by site-directed mutagenesis
CG Wang, N Gilles, A Hamon, F Le Gall, M Stankiewicz, M Pelhate, ...
Biochemistry 42 (16), 4699-4708, 2003
Scanning mutagenesis of ω-atracotoxin-Hv1a reveals a spatially restricted epitope that confers selective activity against insect calcium channels
HW Tedford, N Gilles, A Ménez, CJ Doering, GW Zamponi, GF King
Journal of Biological Chemistry 279 (42), 44133-44140, 2004
Peptidomic comparison and characterization of the major components of the venom of the giant ant Dinoponera quadriceps collected in four different areas of Brazil
CT Cologna, J dos Santos Cardoso, E Jourdan, M Degueldre, G Upert, ...
Journal of proteomics 94, 413-422, 2013
Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the α1A‐adrenoceptor
L Quinton, E Girard, A Maiga, M Rekik, P Lluel, G Masuyer, M Larregola, ...
British journal of pharmacology 159 (2), 316-325, 2010
A new ω-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity
P Favreau, N Gilles, H Lamthanh, R Bournaud, T Shimahara, F Bouet, ...
Biochemistry 40 (48), 14567-14575, 2001
An ‘Old World’scorpion β‐toxin that recognizes both insect and mammalian sodium channels: A possible link towards diversification of β‐toxins
D Gordon, N Ilan, N Zilberberg, N Gilles, D Urbach, L Cohen, I Karbat, ...
European journal of biochemistry 270 (12), 2663-2670, 2003
A scorpion α-like toxin that is active on insects and mammals reveals an unexpected specificity and distribution of sodium channel subtypes in rat brain neurons
N Gilles, C Blanchet, I Shichor, M Zaninetti, I Lotan, D Bertrand, D Gordon
Journal of Neuroscience 19 (20), 8730-8739, 1999
Scorpion α‐like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage‐gated sodium channels in mammals and insects
S Cestele, M Stankiewicz, P Mansuelle, M De Waard, B Dargent, N Gilles, ...
European Journal of Neuroscience 11 (3), 975-985, 1999
Two distinct dopamine D2 receptor genes in the European eel: molecular characterization, tissue-specific transcription, and regulation by sex steroids
C Pasqualini, FA Weltzien, B Vidal, S Baloche, C Rouget, N Gilles, ...
Endocrinology 150 (3), 1377-1392, 2009
The unique pharmacology of the scorpion α‐like toxin Lqh3 is associated with its flexible C‐tail
I Karbat, R Kahn, L Cohen, N Ilan, N Gilles, G Corzo, O Froy, M Gur, ...
The FEBS journal 274 (8), 1918-1931, 2007
δ-Atracotoxins from Australian funnel-web spiders compete with scorpion α-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels
MJ Little, C Zappia, N Gilles, M Connor, MI Tyler, MF Martin-Eauclaire, ...
Journal of Biological Chemistry 273 (42), 27076-27083, 1998
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