Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)–processing enzymes DT King, A Males, GJ Davies, DJ Vocadlo Current opinion in chemical biology 53, 131-144, 2019 | 47 | 2019 |
A family of dual-activity glycosyltransferase-phosphorylases mediates mannogen turnover and virulence in Leishmania parasites MF Sernee, JE Ralton, TL Nero, LF Sobala, J Kloehn, MA Vieira-Lara, ... Cell host & microbe 26 (3), 385-399. e9, 2019 | 37 | 2019 |
Mannosidase mechanism: at the intersection of conformation and catalysis C Rovira, A Males, GJ Davies, SJ Williams Current opinion in structural biology 62, 79-92, 2020 | 32 | 2020 |
Computational design of experiment unveils the conformational reaction coordinate of GH125 α-mannosidases S Alonso-Gil, A Males, PZ Fernandes, SJ Williams, GJ Davies, C Rovira Journal of the American Chemical Society 139 (3), 1085-1088, 2017 | 24 | 2017 |
Crystal structures of penicillin‐binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms J Ren, JE Nettleship, A Males, DI Stuart, RJ Owens FEBS letters 590 (2), 288-297, 2016 | 20 | 2016 |
Conformational analysis of the mannosidase inhibitor kifunensine: a quantum mechanical and structural approach A Males, L Raich, SJ Williams, C Rovira, GJ Davies ChemBioChem 18 (15), 1496-1501, 2017 | 16 | 2017 |
Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications M Gonzalez-Cuesta, P Sidhu, RA Ashmus, A Males, C Proceviat, ... Journal of the American Chemical Society 144 (2), 832-844, 2022 | 15 | 2022 |
Distortion of mannoimidazole supports a B 2, 5 boat transition state for the family GH125 α-1, 6-mannosidase from Clostridium perfringens A Males, G Speciale, SJ Williams, GJ Davies Organic & biomolecular chemistry 17 (34), 7863-7869, 2019 | 12 | 2019 |
Conformational Behaviour of Azasugars Based on Mannuronic Acid ER van Rijssel, APA Janssen, A Males, GJ Davies, GA van der Marel, ... ChemBioChem 18 (13), 1297-1304, 2017 | 10 | 2017 |
Structural studies of a surface-entropy reduction mutant of O-GlcNAcase A Males, GJ Davies Acta Crystallographica Section D: Structural Biology 75 (1), 70-78, 2019 | 4 | 2019 |
Human O-GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics M Calvelo, A Males, MG Alteen, LI Willems, DJ Vocadlo, GJ Davies, ... ACS catalysis 13 (20), 13672-13678, 2023 | 1 | 2023 |
Structure, Function and Mechanism of N‐Glycan Processing Enzymes: endo‐α‐1,2‐Mannanase and endo‐α‐1,2‐Mannosidase L Burchill, A Males, A Kaur, GJ Davies, SJ Williams Israel Journal of Chemistry 63 (1-2), e202200067, 2023 | 1 | 2023 |
Development of Non‐Hydrolysable Oligosaccharide Activity‐Based Inactivators for Endoglycanases: A Case Study on α‐1, 6 Mannanases SP Schröder, WA Offen, A Males, Y Jin, C de Boer, J Enotarpi, L Marino, ... Chemistry–A European Journal 27 (37), 9519-9523, 2021 | 1 | 2021 |
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 a-D-mannosidases through a bump–hole strategy A Males, K Kok, A Nin-Hill, N de Koster | | 2023 |
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy A Males, K Kok, A Nin-Hill, N de Koster, S van den Beukel, ... Chemical Science 14 (46), 13581-13586, 2023 | | 2023 |
Evolution of a New Pathway of Reserve Carbohydrate Biosynthesis in Leishmania Parasites F Sernee, J Ralton, TL Nero, L Sobala, M Viera-Lara, J Kloehn, ... | | 2019 |
Structure and function of glycoside hydrolase enzymes involved in mannose and N-acetylglucosamine processing A Males University of York, 2019 | | 2019 |
Conformational behaviour of mannuronic acid based azasugars E van Rijssel, APA Janssen, A Males, GJ Davies, GA Van der Marel, ... Chembiochem, 1-9, 2017 | | 2017 |
Full wwPDB X-ray Structure Validation Report i LF Sobala, A Males, LM Bastidas, T Ward, MF Sernee, JE Ralton, TL Nero, ... | | |