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Alexandra Males
Alexandra Males
PhD student, University of York
Adresse e-mail validée de york.ac.uk
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Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)–processing enzymes
DT King, A Males, GJ Davies, DJ Vocadlo
Current opinion in chemical biology 53, 131-144, 2019
472019
A family of dual-activity glycosyltransferase-phosphorylases mediates mannogen turnover and virulence in Leishmania parasites
MF Sernee, JE Ralton, TL Nero, LF Sobala, J Kloehn, MA Vieira-Lara, ...
Cell host & microbe 26 (3), 385-399. e9, 2019
372019
Mannosidase mechanism: at the intersection of conformation and catalysis
C Rovira, A Males, GJ Davies, SJ Williams
Current opinion in structural biology 62, 79-92, 2020
322020
Computational design of experiment unveils the conformational reaction coordinate of GH125 α-mannosidases
S Alonso-Gil, A Males, PZ Fernandes, SJ Williams, GJ Davies, C Rovira
Journal of the American Chemical Society 139 (3), 1085-1088, 2017
242017
Crystal structures of penicillin‐binding protein 3 in complexes with azlocillin and cefoperazone in both acylated and deacylated forms
J Ren, JE Nettleship, A Males, DI Stuart, RJ Owens
FEBS letters 590 (2), 288-297, 2016
202016
Conformational analysis of the mannosidase inhibitor kifunensine: a quantum mechanical and structural approach
A Males, L Raich, SJ Williams, C Rovira, GJ Davies
ChemBioChem 18 (15), 1496-1501, 2017
162017
Bicyclic picomolar OGA inhibitors enable chemoproteomic mapping of its endogenous post-translational modifications
M Gonzalez-Cuesta, P Sidhu, RA Ashmus, A Males, C Proceviat, ...
Journal of the American Chemical Society 144 (2), 832-844, 2022
152022
Distortion of mannoimidazole supports a B 2, 5 boat transition state for the family GH125 α-1, 6-mannosidase from Clostridium perfringens
A Males, G Speciale, SJ Williams, GJ Davies
Organic & biomolecular chemistry 17 (34), 7863-7869, 2019
122019
Conformational Behaviour of Azasugars Based on Mannuronic Acid
ER van Rijssel, APA Janssen, A Males, GJ Davies, GA van der Marel, ...
ChemBioChem 18 (13), 1297-1304, 2017
102017
Structural studies of a surface-entropy reduction mutant of O-GlcNAcase
A Males, GJ Davies
Acta Crystallographica Section D: Structural Biology 75 (1), 70-78, 2019
42019
Human O-GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics
M Calvelo, A Males, MG Alteen, LI Willems, DJ Vocadlo, GJ Davies, ...
ACS catalysis 13 (20), 13672-13678, 2023
12023
Structure, Function and Mechanism of N‐Glycan Processing Enzymes: endo‐α‐1,2‐Mannanase and endo‐α‐1,2‐Mannosidase
L Burchill, A Males, A Kaur, GJ Davies, SJ Williams
Israel Journal of Chemistry 63 (1-2), e202200067, 2023
12023
Development of Non‐Hydrolysable Oligosaccharide Activity‐Based Inactivators for Endoglycanases: A Case Study on α‐1, 6 Mannanases
SP Schröder, WA Offen, A Males, Y Jin, C de Boer, J Enotarpi, L Marino, ...
Chemistry–A European Journal 27 (37), 9519-9523, 2021
12021
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 a-D-mannosidases through a bump–hole strategy
A Males, K Kok, A Nin-Hill, N de Koster
2023
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy
A Males, K Kok, A Nin-Hill, N de Koster, S van den Beukel, ...
Chemical Science 14 (46), 13581-13586, 2023
2023
Evolution of a New Pathway of Reserve Carbohydrate Biosynthesis in Leishmania Parasites
F Sernee, J Ralton, TL Nero, L Sobala, M Viera-Lara, J Kloehn, ...
2019
Structure and function of glycoside hydrolase enzymes involved in mannose and N-acetylglucosamine processing
A Males
University of York, 2019
2019
Conformational behaviour of mannuronic acid based azasugars
E van Rijssel, APA Janssen, A Males, GJ Davies, GA Van der Marel, ...
Chembiochem, 1-9, 2017
2017
Full wwPDB X-ray Structure Validation Report i
LF Sobala, A Males, LM Bastidas, T Ward, MF Sernee, JE Ralton, TL Nero, ...
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