|Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine|
A Sparreboom, J Van Asperen, U Mayer, AH Schinkel, JW Smit, ...
Proceedings of the National Academy of Sciences 94 (5), 2031-2035, 1997
|Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan|
JW Jonker, JW Smit, RF Brinkhuis, M Maliepaard, JH Beijnen, ...
Journal of the National Cancer Institute 92 (20), 1651-1656, 2000
|Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure|
JW Smit, MT Huisman, O van Tellingen, HR Wiltshire, AH Schinkel
The Journal of clinical investigation 104 (10), 1441-1447, 1999
|Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.|
U Mayer, E Wagenaar, JH Beijnen, JW Smit, DK Meijer, J van Asperen, ...
British journal of pharmacology 119 (5), 1038, 1996
|Phase I dose-escalation study of JNJ-42756493, an oral pan–fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors|
J Tabernero, R Bahleda, R Dienstmann, JR Infante, A Mita, A Italiano, ...
Journal of clinical oncology 33 (30), 3401-3408, 2015
|Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin …|
A Younes, C Thieblemont, F Morschhauser, I Flinn, JW Friedberg, ...
The Lancet Oncology 15 (9), 1019-1026, 2014
|Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs|
MT Huisman, JW Smit, KML Crommentuyn, N Zelcer, HR Wiltshire, ...
Aids 16 (17), 2295-2301, 2002
|Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism|
AE van Herwaarden, E Wagenaar, CMM van der Kruijssen, ...
The Journal of clinical investigation 117 (11), 3583-3592, 2007
|P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir|
MT Huisman, JW Smit, HR Wiltshire, RMW Hoetelmans, JH Beijnen, ...
Molecular Pharmacology 59 (4), 806-813, 2001
|Significance of P-glycoprotein for the pharmacology and clinical use of HIV protease inhibitors|
MT Huisman, JW Smit, AH Schinkel
Aids 14 (3), 237-242, 2000
|Transport of topoisomerase I inhibitors by the breast cancer resistance protein: potential clinical implications|
JHM Schellens, M Maliepaard, RJ Scheper, GL Scheffer, JW Jonker, ...
Annals of the New York Academy of Sciences 922 (1), 188-194, 2000
|Mrp2 is essential for estradiol-17β (β-D-glucuronide)–induced cholestasis in rats|
L Huang, JW Smit, DK Meijer, M Vore
Hepatology 32 (1), 66-72, 2000
|Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted|
JW Smit, AH Schinkel, B Weert, DKF Meijer
British journal of pharmacology 124 (2), 416-424, 1998
|A Phase I Study of Quisinostat (JNJ-26481585), an Oral Hydroxamate Histone Deacetylase Inhibitor with Evidence of Target Modulation and Antitumor Activity, in Patients with …|
B Venugopal, R Baird, RS Kristeleit, R Plummer, R Cowan, A Stewart, ...
Clinical Cancer Research 19 (15), 4262-4272, 2013
|Contribution of the murine mdr1a P‐glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption|
JW Smit, AH Schinkel, M Müller, B Weert, DKF Meijer
Hepatology 27 (4), 1056-1063, 1998
|Effect of CYP 3A perpetrators on ibrutinib exposure in healthy participants|
J de Jong, D Skee, J Murphy, J Sukbuntherng, P Hellemans, J Smit, ...
Pharmacology research & perspectives 3 (4), e00156, 2015
|Hepatobiliary elimination of cationic drugs: the role of P-glycoproteins and other ATP-dependent transporters|
DKF Meijer, JW Smit, M Müller
Advanced drug delivery reviews 25 (2-3), 159-200, 1997
|Interactions between P‐glycoprotein substrates and other cationic drugs at the hepatic excretory level|
JW Smit, E Duin, H Steen, R Oosting, J Roggeveld, DKF Meijer
British journal of pharmacology 123 (3), 361-370, 1998
|Abiraterone acetate to lower androgens in women with classic 21-hydroxylase deficiency|
RJ Auchus, EO Buschur, AY Chang, GD Hammer, C Ramm, D Madrigal, ...
The Journal of Clinical Endocrinology & Metabolism 99 (8), 2763-2770, 2014
|Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir|
MT Huisman, JW Smit, HR Wiltshire, JH Beijnen, AH Schinkel
Journal of Pharmacology and Experimental Therapeutics 304 (2), 596-602, 2003