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L'homme Laurent
L'homme Laurent
Inserm UMR1011, Lille (France)
Adresse e-mail validée de inserm.fr
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Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
N Esser, L L’homme, A De Roover, L Kohnen, AJ Scheen, M Moutschen, ...
Diabetologia 56 (11), 2487-2497, 2013
2782013
Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages
L L'homme, N Esser, L Riva, A Scheen, N Paquot, J Piette, ...
Journal of lipid research 54 (11), 2998-3008, 2013
1842013
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
S Legrand-Poels, N Esser, L L’homme, A Scheen, N Paquot, J Piette
Biochemical pharmacology 92 (1), 131-141, 2014
1802014
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR
DA Mogilenko, JT Haas, L L’homme, S Fleury, S Quemener, ...
Cell 177 (5), 1201-1216. e19, 2019
1262019
Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption
MA Gianfrancesco, J Dehairs, L L'homme, G Herinckx, N Esser, O Jansen, ...
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2019
752019
Inflammatory properties and adjuvant potential of synthetic glycolipids homologous to mycolate esters of the cell wall of Mycobacterium tuberculosis
HG Tima, O Denis, P Lehebel, KS Baols, MO Mohammed, L L'Homme, ...
Journal of Innate Immunity 9 (2), 162-180, 2017
372017
RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death
G Fettweis, E Di Valentin, L L'homme, C Lassence, F Dequiedt, M Fillet, ...
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1864 (1), 113-124, 2017
232017
Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
L L’homme, BP Sermikli, B Staels, J Piette, S Legrand-Poels, ...
Nutrients 12 (12), 3771, 2020
162020
Identification of piperazinylbenzenesulfonamides as new inhibitors of claudin-1 trafficking and hepatitis C virus entry
L Riva, OR Song, J Prentoe, F Helle, L L'homme, CH Gattolliat, ...
Journal of Virology 92 (10), 10.1128/jvi. 01982-17, 2018
152018
IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women
DA Mogilenko, R Caiazzo, L L’homme, L Pineau, V Raverdy, J Noulette, ...
International Journal of Obesity 45 (7), 1607-1617, 2021
112021
Deletion of the ORF9p acidic cluster impairs the nuclear egress of varicella-zoster virus capsids
L Riva, M Thiry, M Lebrun, L L'homme, J Piette, C Sadzot-Delvaux
Journal of virology 89 (4), 2436-2441, 2015
102015
Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH
L L’homme, BP Sermikli, O Molendi-Coste, S Fleury, S Quemener, ...
Scientific reports 10 (1), 21095, 2020
62020
Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding
A Molinaro, R Caesar, L L'homme, A Koh, M Ståhlman, B Staels, ...
Molecular metabolism 23, 82-87, 2019
42019
Novel XBP1s-independent function of IRE1 RNase in HIF-1α-mediated glycolysis upregulation in human macrophages upon stimulation with LPS or saturated fatty acid
M Iovino, M Colonval, C Wilkin, L L’homme, C Lassence, M Campas, ...
Frontiers in Immunology 14, 2023
32023
in vitro models of human mast cells: How to get more and better with induced pluripotent stem cells?
L L'homme, D Dombrowicz
The Journal of Allergy and Clinical Immunology, 2022
22022
IRE1 endoribonuclease plays a key role in activation of both HIF-1alpha and glucose metabolism in saturated fatty acid-treated human macrophages
M Iovino, C Wilkin, M Colonval, L L'Homme, M Campas, M Schoumacher, ...
Cell Symposium: Translational Immunometabolism, 2022
2022
Key role of the IRE1-XBP1s pathway in metabolic reprogramming of human macrophages in response to saturated fatty acids and LPS
M Iovino, M Colonval, L L'homme, P De Tullio, N Paquot, J Piette, ...
EUROPEAN JOURNAL OF IMMUNOLOGY 51, 242-242, 2021
2021
Astrotactin 1-derived peptide (AP): a new skin-penetrating peptide against inflammatory skin diseases
L L'homme, D Dombrowicz
Journal of Allergy and Clinical Immunology 141 (1), 86-88, 2018
2018
The saturation of membrane phospholipids would be a trigger for K+ efflux and NLRP3 inflammasome activation in human monocytes/macrophages
MA Gianfrancesco, J Dehairs, K Bloch, L L'homme, M Colonval, J Piette, ...
Diabetologia 60, S290-S290, 2017
2017
Investigation of the glycolytic switch induced by saturated fatty acid in human macrophages
M Colonval, G Fettweis, L L'homme, J Piette, S Legrand
Keystone-Integrating metabolism and immunity joint with the meeting on cell …, 2017
2017
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