| Structural analysis reveals that Toll-like receptor 7 is a dual receptor for guanosine and single-stranded RNA Z Zhang, U Ohto, T Shibata, E Krayukhina, M Taoka, Y Yamauchi, H Tanji, ... Immunity 45 (4), 737-748, 2016 | 412 | 2016 |
| Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 U Ohto, T Shibata, H Tanji, H Ishida, E Krayukhina, S Uchiyama, K Miyake, ... Nature 520 (7549), 702-705, 2015 | 384 | 2015 |
| Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands H Tanji, U Ohto, T Shibata, K Miyake, T Shimizu Science 339 (6126), 1426-1429, 2013 | 371 | 2013 |
| Toll-like receptor 8 senses degradation products of single-stranded RNA H Tanji, U Ohto, T Shibata, M Taoka, Y Yamauchi, T Isobe, K Miyake, ... Nature structural & molecular biology 22 (2), 109-115, 2015 | 370 | 2015 |
| A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses K Takahashi, T Shibata, S Akashi-Takamura, T Kiyokawa, Y Wakabayashi, ... The Journal of experimental medicine 204 (12), 2963-2976, 2007 | 228 | 2007 |
| Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking R Fukui, SI Saitoh, A Kanno, M Onji, T Shibata, A Ito, M Onji, M Matsumoto, ... Immunity 35 (1), 69-81, 2011 | 222 | 2011 |
| Crystal structure of NOD2 and its implications in human disease S Maekawa, U Ohto, T Shibata, K Miyake, T Shimizu Nature communications 7 (1), 11813, 2016 | 159 | 2016 |
| DNase II-dependent DNA digestion is required for DNA sensing by TLR9 MP Chan, M Onji, R Fukui, K Kawane, T Shibata, S Saitoh, U Ohto, ... Nature communications 6 (1), 5853, 2015 | 126 | 2015 |
| Structural analyses of toll-like receptor 7 reveal detailed RNA sequence specificity and recognition mechanism of agonistic ligands Z Zhang, U Ohto, T Shibata, M Taoka, Y Yamauchi, R Sato, NM Shukla, ... Cell reports 25 (12), 3371-3381. e5, 2018 | 120 | 2018 |
| Guanosine and its modified derivatives are endogenous ligands for TLR7 T Shibata, U Ohto, S Nomura, K Kibata, Y Motoi, Y Zhang, Y Murakami, ... International immunology 28 (5), 211-222, 2016 | 113 | 2016 |
| Nucleic acid‐sensing TLR s and autoimmunity: novel insights from structural and cell biology K Pelka, T Shibata, K Miyake, E Latz Immunological Reviews 269 (1), 60-75, 2016 | 113 | 2016 |
| Toll-like receptor 9 contains two DNA binding sites that function cooperatively to promote receptor dimerization and activation U Ohto, H Ishida, T Shibata, R Sato, K Miyake, T Shimizu Immunity 48 (4), 649-658. e4, 2018 | 112 | 2018 |
| Mechanisms controlling nucleic acid-sensing Toll-like receptors K Miyake, T Shibata, U Ohto, T Shimizu, SI Saitoh, R Fukui, Y Murakami International immunology 30 (2), 43-51, 2018 | 95 | 2018 |
| An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing M Onji, A Kanno, SI Saitoh, R Fukui, Y Motoi, T Shibata, F Matsumoto, ... Nature communications 4 (1), 1949, 2013 | 95 | 2013 |
| TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells SI Saitoh, F Abe, A Kanno, N Tanimura, Y Mori Saitoh, R Fukui, T Shibata, ... Nature communications 8 (1), 1592, 2017 | 93 | 2017 |
| UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5 JW Huh, T Shibata, M Hwang, EH Kwon, MS Jang, R Fukui, A Kanno, ... Proceedings of the National Academy of Sciences 111 (19), 7072-7077, 2014 | 78 | 2014 |
| Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases A Kanno, N Tanimura, M Ishizaki, K Ohko, Y Motoi, M Onji, R Fukui, ... Nature communications 6 (1), 6119, 2015 | 77 | 2015 |
| Intracellular TLR4/MD-2 in macrophages senses Gram-negative bacteria and induces a unique set of LPS-dependent genes T Shibata, Y Motoi, N Tanimura, N Yamakawa, S Akashi-Takamura, ... International immunology 23 (8), 503-510, 2011 | 71 | 2011 |
| Mechanical augmentation of the vertebral body by calcium phosphate cement injection M Ikeuchi, H Yamamoto, T Shibata, M Otani Journal of orthopaedic science 6 (1), 39-45, 2001 | 66 | 2001 |
| Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis R Sato, A Kato, T Chimura, SI Saitoh, T Shibata, Y Murakami, R Fukui, ... Nature immunology 19 (10), 1071-1082, 2018 | 63 | 2018 |
