Panagis Filippakopoulos
Panagis Filippakopoulos
Associate Professor, Oxford University
Adresse e-mail validée de sgc.ox.ac.uk - Page d'accueil
TitreCitée parAnnée
Selective inhibition of BET bromodomains
P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ...
Nature 468 (7327), 1067, 2010
24442010
Histone recognition and large-scale structural analysis of the human bromodomain family
P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ...
Cell 149 (1), 214-231, 2012
9042012
Targeting bromodomains: epigenetic readers of lysine acetylation
P Filippakopoulos, S Knapp
Nature reviews Drug discovery 13 (5), 337-356, 2014
7592014
Large-scale structural analysis of the classical human protein tyrosine phosphatome
AJ Barr, E Ugochukwu, WH Lee, ONF King, P Filippakopoulos, I Alfano, ...
Cell 136 (2), 352-363, 2009
3842009
Bromodomains as therapeutic targets
S Muller, P Filippakopoulos, S Knapp
Expert reviews in molecular medicine 13, 2011
3562011
Small-molecule inhibition of BRDT for male contraception
MM Matzuk, MR McKeown, P Filippakopoulos, Q Li, L Ma, JE Agno, ...
Cell 150 (4), 673-684, 2012
3262012
The bromodomain interaction module
P Filippakopoulos, S Knapp
FEBS letters 586 (17), 2692-2704, 2012
2952012
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ...
Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013
2432013
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
P Ciceri, S Müller, A O'mahony, O Fedorov, P Filippakopoulos, JP Hunt, ...
Nature chemical biology 10 (4), 305, 2014
2262014
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
N Kwiatkowski, N Jelluma, P Filippakopoulos, M Soundararajan, ...
Nature chemical biology 6 (5), 359, 2010
2142010
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
1952014
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation
P Filippakopoulos, M Kofler, O Hantschel, GD Gish, F Grebien, E Salah, ...
Cell 134 (5), 793-803, 2008
1872008
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains
S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ...
Cancer research 73 (11), 3336-3346, 2013
1852013
Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors
L Feng, Y Geisselbrecht, S Blanck, A Wilbuer, GE Atilla-Gokcumen, ...
Journal of the American Chemical Society 133 (15), 5976-5986, 2011
1842011
Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity
V Pogacic, AN Bullock, O Fedorov, P Filippakopoulos, C Gasser, A Biondi, ...
Cancer research 67 (14), 6916-6924, 2007
1832007
3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ...
Journal of medicinal chemistry 54 (19), 6761-6770, 2011
1782011
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ...
Journal of medicinal chemistry 55 (22), 9831-9837, 2012
1662012
Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing
O Fedorov, K Huber, A Eisenreich, P Filippakopoulos, O King, AN Bullock, ...
Chemistry & biology 18 (1), 67-76, 2011
1492011
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B
T Tahtouh, JM Elkins, P Filippakopoulos, M Soundararajan, G Burgy, ...
Journal of medicinal chemistry 55 (21), 9312-9330, 2012
1442012
Functions of bromodomain-containing proteins and their roles in homeostasis and cancer
T Fujisawa, P Filippakopoulos
Nature reviews Molecular cell biology 18 (4), 246, 2017
1402017
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