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Spyros K Stamatelos
Spyros K Stamatelos
Bayer Pharmaceuticals
Adresse e-mail validée de bayer.com
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A bioimage informatics based reconstruction of breast tumor microvasculature with computational blood flow predictions
SK Stamatelos, E Kim, AP Pathak, AS Popel
Microvascular research 91, 8-21, 2014
1012014
Multiscale imaging and computational modeling of blood flow in the tumor vasculature
E Kim, S Stamatelos, J Cebulla, ZM Bhujwalla, AS Popel, AP Pathak
Annals of biomedical engineering 40, 2425-2441, 2012
762012
Tumor ensemble-based modeling and visualization of emergent angiogenic heterogeneity in breast cancer
SK Stamatelos, A Bhargava, E Kim, AS Popel, AP Pathak
Scientific reports 9 (1), 5276, 2019
282019
Mathematical model of uptake and metabolism of arsenic (III) in human hepatocytes-Incorporation of cellular antioxidant response and threshold-dependent behavior
SK Stamatelos, CJ Brinkerhoff, SS Isukapalli, PG Georgopoulos
BMC systems biology 5, 1-15, 2011
212011
Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer
M Bouhaddou, LJ Yu, S Lunardi, SK Stamatelos, F Mack, JM Gallo, ...
Clinical and Translational Science 13 (2), 419-429, 2020
192020
A semi-mechanistic integrated toxicokinetic–toxicodynamic (TK/TD) model for arsenic (III) in hepatocytes
SK Stamatelos, IP Androulakis, ANT Kong, PG Georgopoulos
Journal of theoretical biology 317, 244-256, 2013
142013
From cold to hot: changing perceptions and future opportunities for quantitative systems pharmacology modeling in cancer immunotherapy
V Lemaire, D Bassen, M Reed, R Song, S Khalili, YT Lien, L Huang, ...
Clinical Pharmacology & Therapeutics 113 (5), 963-972, 2023
82023
Quantitative systems pharmacology modeling sheds light into the dose response relationship of a trispecific T cell engager in multiple myeloma
RE Abrams, K Pierre, N El-Murr, E Seung, L Wu, E Luna, R Mehta, J Li, ...
Scientific Reports 12 (1), 10976, 2022
72022
Image‐based Characterization of Functional and Structural Heterogeneity of Tumor Xenografts using Blood Flow modeling, Oxygenation Modeling and Multivariate Analysis
S Stamatelos, E Kim, A Pathak, A Popel
The FASEB Journal 29, 787.11, 2015
12015
Abstract CT276: Preliminary analysis of pharmacokinetic (PK) and target engagement biomarkers from a first in human phase 1 study of immunomodulatory aryl hydrocarbon receptor …
K Papadopoulos, M Cecchini, JS Lopez, D Jäger, KY Chung, M Platten, ...
Cancer Research 83 (8_Supplement), CT276-CT276, 2023
2023
PREDICTING DRUG EFFICACY AND CYTOKINE RELEASE WITH A VERSATILE QUANTITATIVE SYSTEMS PHARMACOLOGY (QSP) MODELING STRATEGY FOR MULTISPECIFIC T-CELL ENGAGERS.
R Abrams, K Pierre, N El-Murr, A Li, J Fretland, J Li, L Wu, E Seung, ...
CLINICAL PHARMACOLOGY & THERAPEUTICS 107, S114-S114, 2020
2020
Development of a multiscale QSP model to characterize the tumor suppressive effects of a cytokine mRNA immunotherapy in a preclinical melanoma mouse model
K Pierre, L Lin, L Gruenbaum, C Young, J Apgar, C Hotz, T Wagenaar, ...
Cancer Research 79 (13_Supplement), 685-685, 2019
2019
Development of an Integrated Human Model of Electrophysiology and Actin-Myosin Binding to Describe Sarcomere Force Generation in Cardiomyocytes
RE Abrams, HC Schneider, T Radziun, B Goebel, L Lucats, K Azer, ...
Biophysical Journal 116 (3), 422a-423a, 2019
2019
Development of a multiscale model for heart failure focusing on cardiac myosin modulators
SK Stamatelos, R Abrams, E Sobie, L Lucats, H Surks, ...
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 45, S125-S125, 2018
2018
Predicting in vivo efficacy from in vitro data: Quantitative systems pharmacology modeling for an epigenetic modifier drug in cancer
M Bouhaddou, LJ Yu, S Lunardi, SK Stamatelos, F Mack, JM Gallo, ...
Cancer Research 78 (13_Supplement), 2796-2796, 2018
2018
Characterization of tumor heterogeneity using bioimage informatics and 3D computational modeling
S Stamatelos, A Carlier, E Kim, A Pathak, A Popel
Meeting of the Biomedical Engineering Society, 2013
2013
Identification of morphological and hemodynamic biomarkers for tumor vascular perfusion through mathematical modeling and high‐resolution imaging
SK Stamatelos, E Kim, AP Pathak, AS Popel
The FASEB Journal 27, 685.12-685.12, 2013
2013
In Silico Modeling of Uptake and Metabolism of Arsenicals In Hepatocytes with Implications for Hepatotoxicity
SK Stamatelos, CJ Brinkerhoff, AF Sasso, SS Isukapalli, ...
2008 AIChE Annual Meeting, AIChE 100, 2008
2008
Population Approach Group Europe Population Approach Group Europe
S Stamatelos
765a In Silico Modeling of Uptake and Metabolism of Arsenicals In Hepatocytes with Implications for Hepatotoxicity
SK Stamatelos
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