Frank Niesen
Frank Niesen
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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
FH Niesen, H Berglund, M Vedadi
Nature protocols 2 (9), 2212, 2007
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene.
P Rehling, M Marzioch, F Niesen, E Wittke, M Veenhuis, WH Kunau
The EMBO Journal 15 (12), 2901-2913, 1996
Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp
PLoS Biol 8 (7), e1000426, 2010
Activation segment dimerization: a mechanism for kinase autophosphorylation of non‐consensus sites
ACW Pike, P Rellos, FH Niesen, A Turnbull, AW Oliver, SA Parker, ...
The EMBO journal 27 (4), 704-714, 2008
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer
GB Deutsch, EM Zielonka, D Coutandin, TA Weber, B Schäfer, ...
Cell 144 (4), 566-576, 2011
Kinase inhibitor selectivity profiling using differential scanning fluorimetry
O Fedorov, FH Niesen, S Knapp
Kinase Inhibitors, 109-118, 2012
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation
AN Bullock, S Das, JÉ Debreczeni, P Rellos, O Fedorov, FH Niesen, ...
Structure 17 (3), 352-362, 2009
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins
O Gileadi, S Knapp, WH Lee, BD Marsden, S Müller, FH Niesen, ...
Journal of structural and functional genomics 8 (2-3), 107-119, 2007
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization
AP Turnbull, D Kümmel, B Prinz, C Holz, J Schultchen, C Lang, ...
The EMBO journal 24 (5), 875-884, 2005
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
B Lucic, Y Zhang, O King, R Mendoza-Maldonado, M Berti, FH Niesen, ...
Nucleic acids research 39 (5), 1703-1717, 2011
Conformational stability and activity of p73 require a second helix in the tetramerization domain
D Coutandin, F Löhr, FH Niesen, T Ikeya, TA Weber, B Schäfer, ...
Cell Death & Differentiation 16 (12), 1582-1589, 2009
Structural basis for substrate specificity in human monomeric carbonyl reductases
ES Pilka, FH Niesen, WH Lee, Y El-Hawari, JE Dunford, G Kochan, ...
PloS one 4 (10), e7113, 2009
An automated in vitro protein folding screen applied to a human dynactin subunit
C Scheich, FH Niesen, R Seckler, K Büssow
Protein Science 13 (2), 370-380, 2004
Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder
DS Froese, S Healy, M McDonald, G Kochan, U Oppermann, FH Niesen, ...
Molecular genetics and metabolism 100 (1), 29-36, 2010
High-affinity inhibitors of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase: Mechanisms of inhibition and structure-activity relationships
FH Niesen, L Schultz, A Jadhav, C Bhatia, K Guo, DJ Maloney, ES Pilka, ...
PloS one 5 (11), e13719, 2010
Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone
TJ Zimmermann, FH Niesen, ES Pilka, S Knapp, U Oppermann, ME Maier
Bioorganic & medicinal chemistry 17 (2), 530-536, 2009
X‐ray structure of human gankyrin, the product of a gene linked to hepatocellular carcinoma
BA Manjasetty, C Quedenau, V Sievert, K Büssow, F Niesen, H Delbrück, ...
Proteins: Structure, Function, and Bioinformatics 55 (1), 214-217, 2004
An approach to quality management in structural biology: biophysical selection of proteins for successful crystallization
FH Niesen, A Koch, U Lenski, U Harttig, Y Roske, U Heinemann, ...
Journal of structural biology 162 (3), 451-459, 2008
A catalog of human cDNA expression clones and its application to structural genomics
K Büssow, C Quedenau, V Sievert, J Tischer, C Scheich, H Seitz, B Hieke, ...
Genome biology 5 (9), R71, 2004
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