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Hugues Aschard
Hugues Aschard
Institut Pasteur & Harvard School of Public Health
Adresse e-mail validée de pasteur.fr
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Année
Fungal microbiota dysbiosis in IBD
H Sokol, V Leducq, H Aschard, HP Pham, S Jegou, C Landman, D Cohen, ...
Gut 66 (6), 1039-1048, 2017
11092017
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
7002021
Effect of 17q21 variants and smoking exposure in early-onset asthma
E Bouzigon, E Corda, H Aschard, MH Dizier, A Boland, J Bousquet, ...
New England journal of medicine 359 (19), 1985-1994, 2008
4962008
Autoantibodies neutralizing type I IFNs are present in~ 4% of uninfected individuals over 70 years old and account for~ 20% of COVID-19 deaths
P Bastard, A Gervais, T Le Voyer, J Rosain, Q Philippot, J Manry, ...
Science immunology 6 (62), eabl4340, 2021
4222021
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
X Jiang, PF O’Reilly, H Aschard, YH Hsu, JB Richards, J Dupuis, ...
Nature communications 9 (1), 260, 2018
3712018
Adjusting for heritable covariates can bias effect estimates in genome-wide association studies
H Aschard, BJ Vilhjálmsson, AD Joshi, AL Price, P Kraft
The American Journal of Human Genetics 96 (2), 329-339, 2015
2852015
Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr
F Privé, H Aschard, A Ziyatdinov, MGB Blum
Bioinformatics 34 (16), 2781-2787, 2018
2542018
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma
JNC Bailey, SJ Loomis, JH Kang, RR Allingham, P Gharahkhani, CC Khor, ...
Nature genetics 48 (2), 189-194, 2016
2522016
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
B Piasecka, D Duffy, A Urrutia, H Quach, E Patin, C Posseme, J Bergstedt, ...
Proceedings of the National Academy of Sciences 115 (3), E488-E497, 2018
2012018
Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies
H Aschard, BJ Vilhjálmsson, N Greliche, PE Morange, DA Trégouët, ...
The American Journal of Human Genetics 94 (5), 662-676, 2014
1922014
A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries
D Skurnik, D Roux, H Aschard, V Cattoir, D Yoder-Himes, S Lory, GB Pier
PLoS pathogens 9 (9), e1003582, 2013
1812013
Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort
F Privé, H Aschard, S Carmi, L Folkersen, C Hoggart, PF O’Reilly, ...
The American Journal of Human Genetics 109 (1), 12-23, 2022
1752022
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
DB Hancock, MS Artigas, SA Gharib, A Henry, A Manichaikul, ...
PLoS genetics 8 (12), e1003098, 2012
1722012
Current challenges and new opportunities for gene-environment interaction studies of complex diseases
K McAllister, LE Mechanic, C Amos, H Aschard, IA Blair, N Chatterjee, ...
American journal of epidemiology 186 (7), 753-761, 2017
1712017
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies
H Aschard, S Lutz, B Maus, EJ Duell, TE Fingerlin, N Chatterjee, P Kraft, ...
Human genetics 131, 1591-1613, 2012
1682012
Fitness cost of antibiotic susceptibility during bacterial infection
D Roux, O Danilchanka, T Guillard, V Cattoir, H Aschard, Y Fu, ...
Science translational medicine 7 (297), 297ra114-297ra114, 2015
1552015
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
L Fachal, H Aschard, J Beesley, DR Barnes, J Allen, S Kar, KA Pooley, ...
Nature genetics 52 (1), 56-73, 2020
1542020
Making the most of clumping and thresholding for polygenic scores
F Privé, BJ Vilhjálmsson, H Aschard, MGB Blum
The American journal of human genetics 105 (6), 1213-1221, 2019
1502019
lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals
A Ziyatdinov, M Vázquez-Santiago, H Brunel, A Martinez-Perez, ...
BMC bioinformatics 19, 1-5, 2018
1462018
Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing
D Skurnik, D Roux, V Cattoir, O Danilchanka, X Lu, DR Yoder-Himes, ...
Proceedings of the National Academy of Sciences 110 (51), 20747-20752, 2013
1462013
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