Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers R Kayed, E Head, F Sarsoza, T Saing, CW Cotman, M Necula, L Margol, ... Molecular neurodegeneration 2, 1-11, 2007 | 871 | 2007 |
α-Synuclein misfolding and Parkinson's disease L Breydo, JW Wu, VN Uversky Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822 (2), 261-285, 2012 | 820 | 2012 |
Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide E Cerf, R Sarroukh, S Tamamizu-Kato, L Breydo, S Derclaye, YF Dufrêne, ... Biochemical Journal 421 (3), 415-423, 2009 | 552 | 2009 |
In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrPSc OV Bocharova, L Breydo, AS Parfenov, VV Salnikov, IV Baskakov Journal of molecular biology 346 (2), 645-659, 2005 | 317 | 2005 |
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau LJ Blair, BA Nordhues, SE Hill, KM Scaglione, JC O’Leary, SN Fontaine, ... The Journal of clinical investigation 123 (10), 4158-4169, 2013 | 308 | 2013 |
Methylene blue inhibits amyloid Aβ oligomerization by promoting fibrillization M Necula, L Breydo, S Milton, R Kayed, WE Van Der Veer, P Tone, ... Biochemistry 46 (30), 8850-8860, 2007 | 262 | 2007 |
Copper (II) inhibits in vitro conversion of prion protein into amyloid fibrils OV Bocharova, L Breydo, VV Salnikov, IV Baskakov Biochemistry 44 (18), 6776-6787, 2005 | 216 | 2005 |
Beyond the excluded volume effects: mechanistic complexity of the crowded milieu IM Kuznetsova, BY Zaslavsky, L Breydo, KK Turoverov, VN Uversky Molecules 20 (1), 1377-1409, 2015 | 209 | 2015 |
Structural, morphological, and functional diversity of amyloid oligomers L Breydo, VN Uversky FEBS letters 589 (19), 2640-2648, 2015 | 200 | 2015 |
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid β but do not seed fibril formation JW Wu, L Breydo, JM Isas, J Lee, YG Kuznetsov, R Langen, C Glabe Journal of Biological Chemistry 285 (9), 6071-6079, 2010 | 198 | 2010 |
Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers R Kayed, I Canto, L Breydo, S Rasool, T Lukacsovich, J Wu, R Albay, ... Molecular neurodegeneration 5, 1-10, 2010 | 180 | 2010 |
Polymorphism and ultrastructural organization of prion protein amyloid fibrils: an insight from high resolution atomic force microscopy M Anderson, OV Bocharova, N Makarava, L Breydo, VV Salnikov, ... Journal of molecular biology 358 (2), 580-596, 2006 | 147 | 2006 |
Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases L Breydo, VN Uversky Metallomics 3 (11), 1163-1180, 2011 | 142 | 2011 |
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread GG Kovacs, L Breydo, R Green, V Kis, G Puska, P Lőrincz, ... Neurobiology of disease 69, 76-92, 2014 | 137 | 2014 |
Chemoenzymatic Synthesis of HIV-1 V3 Glycopeptides Carrying Two N-Glycans and Effects of Glycosylation on the Peptide Domain H Li, B Li, H Song, L Breydo, IV Baskakov, LX Wang The Journal of organic chemistry 70 (24), 9990-9996, 2005 | 112 | 2005 |
Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic CreutzfeldtJakob Disease OV Bocharova, L Breydo, VV Salnikov, AC Gill, IV Baskakov Protein science 14 (5), 1222-1232, 2005 | 110 | 2005 |
The crowd you're in with: effects of different types of crowding agents on protein aggregation L Breydo, KD Reddy, A Piai, IC Felli, R Pierattelli, VN Uversky Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1844 (2), 346-357, 2013 | 97 | 2013 |
Methionine oxidation interferes with conversion of the prion protein into the fibrillar proteinase K-resistant conformation L Breydo, OV Bocharova, N Makarava, VV Salnikov, M Anderson, ... Biochemistry 44 (47), 15534-15543, 2005 | 97 | 2005 |
Structural differences between amyloid beta oligomers L Breydo, D Kurouski, S Rasool, S Milton, JW Wu, VN Uversky, IK Lednev, ... Biochemical and biophysical research communications 477 (4), 700-705, 2016 | 94 | 2016 |
Annealing prion protein amyloid fibrils at high temperature results in extension of a proteinase K-resistant core OV Bocharova, N Makarava, L Breydo, M Anderson, VV Salnikov, ... Journal of Biological Chemistry 281 (4), 2373-2379, 2006 | 85 | 2006 |